Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4119366 | 0.87 | MAOB (0.40) | MEN1KMT2AHSD11B1CREBBPPTPN1 | |
| SCHEMBL4125320 | 0.85 | PTPN1 (0.41) | GAANPSR1PDE4BMEN1KMT2A | |
| SCHEMBL2968461 | 0.84 | ALDH1A1 (0.50) | CYP3A4MAPK1 | |
| SCHEMBL5618972 | 0.84 | MEN1 (0.43) | PDE4BMEN1KMT2AHSD11B1CREBBP | |
| SCHEMBL30065877 | 0.84 | ALDH1A1 (0.50) | CYP3A4MAPK1 | |
| SCHEMBL3685410 | 0.83 | MAOB (0.43) | MEN1KMT2AHSD11B1CTSDBACE1 | |
| SCHEMBL27445640 | 0.83 | HSD11B1 (0.41) | PDE4BMEN1KMT2AHSD11B1CREBBP | |
| SCHEMBL8771671 | 0.81 | KDM4E (0.45) | NPSR1PDE4BMEN1KMT2APTPN1 | |
| SCHEMBL2281345 | 0.79 | SMN1; SMN2 (0.60) | GAAMEN1KMT2ACREBBPLMNA | |
| SCHEMBL16991669 | 0.78 | PDE4B (0.42) | PDE4BMEN1KMT2AHSD11B1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040176471-A1 | Novel chalcone derivatives and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176471-A1 | Novel chalcone derivatives and pharmaceutical compositions comprising the same | PTGS1, PTGES2, PTGES | GAA 1215/4885NPSR1 2048/4885PDE4B 956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.