Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | CRAT | P43155 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779976 | 0.98 | TGFBR1 (0.46) | TGFBR1MAPTSMN1; SMN2GALR3BLM | |
| SCHEMBL7561035 | 0.84 | TGFBR1 (0.39) | TGFBR1MAPTSMN1; SMN2GALR3BLM | |
| SCHEMBL28040128 | 0.80 | TGFBR1 (0.44) | TGFBR1MAPTSMN1; SMN2GALR3BLM | |
| Bromide SCHEMBL6117103 | 0.79 | TGFBR1 (0.41) | TGFBR1RXFP1 | |
| SCHEMBL17479135 | 0.78 | TGFBR1 (0.40) | TGFBR1 | |
| SCHEMBL554944 | 0.77 | TGFBR1 (0.48) | TGFBR1SMN1; SMN2TSHRRXFP1KDM4E | |
| SCHEMBL18641077 | 0.77 | TGFBR1 (0.48) | TGFBR1SMN1; SMN2TSHRLMNARXFP1 | |
| SCHEMBL9193899 | 0.77 | TGFBR1 (0.59) | TGFBR1BLMTSHRRXFP1KDM4E | |
| Hydrochloric Acid SCHEMBL6116631 | 0.76 | MAPT (0.39) | TGFBR1MAPTSMN1; SMN2GALR3BLM | |
| SCHEMBL9500975 | 0.75 | TGFBR1 (0.47) | TGFBR1TSHRRXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 159 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113242891-A | Polishing slurry composition | 凯斯科技股份有限公司 | 2021-08-10 | — | — | CN | claimed |
| US-20210009815-A1 | CURABLE FILM-FORMING SOL-GEL COMPOSITIONS AND ANTI-GLARE COATED ARTICLES FORMED FROM THEM | PPG INDUSTRIES OHIO, INC. | 2021-01-14 | — | — | US | claimed |
| US-10723890-B2 | Curable film-forming sol-gel compositions and anti-glare coated articles formed from them | PPG INDUSTRIES OHIO, INC. (US) | 2020-07-28 | — | — | US | claimed |
| US-20160166693-A1 | RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2016-06-16 | — | — | US | claimed |
| US-20120197060-A1 | RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY TECHNOLOGY | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2012-08-02 | — | — | US | claimed |
| WO-2010148163-A1 | RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2010-12-23 | — | — | WO | claimed |
| US-6881798-B2 | Method of preparing exfoliated nitropolymer/silicate nanocomposites and the nanocomposites prepared by the method | SAMSUNG ATOFINA CO. LTD. (KR) | 2005-04-19 | — | — | US | claimed |
| US-20050065248-A1 | METHOD OF PREPARING EXFOLIATED NITROPOLYMER/SILICATE NANOCOMPOSITES AND THE NANOCOMPOSITES PREPARED BY THE METHOD | SAMSUNG GENERAL CHEMICALS CO., LTD. (KR) | 2005-03-24 | — | — | US | claimed |
| US-20030050382-A1 | Method for synthesis of exfoliated polymer/silicate nanocomposite | KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY | 2003-03-13 | — | — | US | claimed |
| EP-1291364-A2 | Method for the manufacture of exfoliated polymer/silicate nano-composites | Korea Advanced Institute of Science and Technology (KR) | 2003-03-12 | — | — | EP | claimed |
| CN-107109121-B | Curable film-forming sol-gel compositions and antiglare coated articles formed therefrom | PPG工业俄亥俄公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-109562042-B | Personal care composition for keratinous substrates comprising conditioning, color care and styling polymers | ISP投资有限公司 | 2023-02-21 | — | — | CN | disclosed |
| EP-3224216-B1 | CURABLE FILM-FORMING SOL-GEL COMPOSITIONS AND ANTI-GLARE COATED ARTICLES FORMED FROM THEM | PPG IND OHIO INC (US) | 2022-01-19 | — | — | EP | disclosed |
| US-10962695-B2 | Optical reflection film | Konica Minolta, Inc. (JP) | 2021-03-30 | — | — | US | disclosed |
| US-10908327-B2 | Optical reflection film and optical reflector | Konica Minolta, Inc. (JP) | 2021-02-02 | — | — | US | disclosed |
| EP-1284199-A2 | Ink-jet recording medium and ink-jet image forming method using the recording medium | KONICA CORPORATION (JP) | 2003-02-19 | — | — | EP | disclosed |
| EP-1284186-A2 | Fixing belt, fixing roller, production method thereof, fixing apparatus and image fixing method utilizing the apparatus | KONICA CORPORATION (JP) | 2003-02-19 | — | — | EP | disclosed |
| US-20020115773-A1 | Polyvinyl alcohol, at least two cationic polymers having a quarternary ammonium salt group in the molecule, and a compound containing a zirconium atom or an aluminum atom other than zirconium oxide and aluminum oxide. | KONICA CORPORATION (JP) | 2002-08-22 | — | — | US | disclosed |
| US-20020094420-A1 | Ink jet recording sheet | KONICA CORPORATION (JP) | 2002-07-18 | — | — | US | disclosed |
| WO-2002010229-A1 | WATER-SOLUBLE OR WATER-SWELLABLE, ASSOCIATIVELY THICKENING COPOLYMERS CONTAINING SULFO GROUPS, METHOD FOR PRODUCING THE SAME AND USE THEREOF | DEGUSSA BAUCHEMIE GMBH (DE) | 2002-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160166693-A1 | RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY | MRE11, TOP2A, MTREX | CHRM2 4788/4885CHRM1 4676/4885CHRM3 4716/4885 |
| US-20120197060-A1 | RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY TECHNOLOGY | MRE11, MTREX, POLG | CHRM2 4785/4885CHRM1 4671/4885CHRM3 4691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.