Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL567721 | 0.91 | MTNR1A (0.47) | DRD2ADRA2AADRA2BADRA2C | |
| SCHEMBL567079 | 0.90 | DRD2 (0.57) | DRD2ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL566654 | 0.84 | ADRA2A (0.57) | DRD2ADRA2AADRA2BADRA2CADRA1D | |
| Hydrochloric Acid SCHEMBL9692399 | 0.83 | ADRA2A (0.56) | DRD2ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL568215 | 0.75 | DRD2 (0.52) | DRD2ADRA2AADRA2BADRA2CADRA1D | |
| Hydrochloric Acid SCHEMBL9692447 | 0.75 | DRD2 (0.51) | DRD2ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL566562 | 0.75 | ALDH1A1 (0.59) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL10372041 | 0.74 | ADRA2A (0.63) | DRD2ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8132707 | 0.74 | DRD2 (0.58) | DRD2ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8131179 | 0.73 | HTR1A (0.65) | DRD2ADRA2AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176252-A1 | 2, 3-DIHYDROBENZO[1, 4]DIOXIN-2-YLMETHYL DERIVATIVES AS ALPHA2C ANTAGONISTS FOR USE IN THE TREATMENT OF PERIPHERIC AND CENTRAL NERVOUS SYSTEME DISEASES | ORION CORPORATION (FI) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009013390-A1 | 2, 3-DIHYDROBENZO[1, 4] DIOXIN-2-YLMETHYL DERIVATIVES AS ALPHA2C ANTAGONISTS FOR USE IN THE TREATMENT OF PERIPHERIC AND CENTRAL NERVOUS SYSTEME DISEASES | ORION CORPORATION (FI) | 2009-01-29 | — | — | WO | disclosed |