Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 1.00 |
| ▸ | RAB9A | P51151 | 13/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.72 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26626249 | 0.76 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL12010951 | 0.72 | SMN1; SMN2 (0.74) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL10867492 | 0.72 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL10666500 | 0.72 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL9517906 | 0.71 | RAB9A (0.66) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16972936 | 0.71 | HPGD (0.74) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7878152 | 0.71 | RAB9A (0.54) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16998660 | 0.70 | RAB9A (0.68) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8433045 | 0.68 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5623032 | 0.68 | DDAH1 (0.65) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008029152-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2008-03-13 | — | — | WO | disclosed |