Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364104 | 0.83 | PDE10A (0.59) | PDE10AKMT2AMEN1KDM4E | |
| SCHEMBL9258182 | 0.75 | HTR3E (0.49) | PDE10AKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL18304738 | 0.74 | ADORA2A (0.53) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL31461670 | 0.71 | KDM4E (0.42) | PDE10AKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL31461727 | 0.71 | TSHR (0.42) | PDE10AKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL8357609 | 0.69 | KMT2A (0.46) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL31461679 | 0.66 | KDM4E (0.36) | PDE10AKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL18304786 | 0.66 | ADORA2A (0.53) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL1161180 | 0.65 | LMNA (0.68) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL9315070 | 0.64 | MAOA (0.45) | KMT2AKDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |