Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3759451 | 0.79 | LMNA (0.65) | LMNAALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL3699711 | 0.75 | LMNA (1.00) | LMNAALDH1A1KMT2AELANECYP2D6 | |
| SCHEMBL3705568 | 0.74 | KDM4E (0.63) | LMNAALDH1A1KMT2APOLBCYP2C19 | |
| SCHEMBL22737773 | 0.74 | ALDH1A1 (0.72) | LMNAALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL3705132 | 0.71 | LMNA (0.55) | LMNAALDH1A1CYP2D6CYP2C19CHEK1 | |
| SCHEMBL4188992 | 0.69 | LMNA (0.52) | LMNAALDH1A1KMT2APOLBCYP2D6 | |
| SCHEMBL5062373 | 0.67 | KIF11 (0.51) | LMNAALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL5062378 | 0.67 | KIF11 (0.51) | LMNAALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL14627842 | 0.67 | LMNA (0.65) | LMNAALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL3708958 | 0.67 | TDO2 (0.44) | LMNAPOLBCYP2D6KDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609674-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2013-12-17 | — | — | US | disclosed |
| WO-2012067824-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |
| US-20120122890-A1 | Potassium Channel Modulators | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122890-A1 | Potassium Channel Modulators | KCNQ1, KCNQ2, KCNQ3 | LMNA 306/4885ALDH1A1 2393/4885KMT2A 432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.