Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | VDR | P11473 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | LIFR | P42702 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3701994 | 0.92 | NR1H4 (0.46) | NR1H4HPGDLMNASMPD1MAPT | |
| SCHEMBL3714395 | 0.85 | NR1H4 (0.40) | NR1H4HPGDLMNAMAPT | |
| SCHEMBL3708634 | 0.85 | ALDH1A1 (0.42) | NR1H4SMPD1VDRESR1THRA | |
| SCHEMBL3702563 | 0.83 | NR1H4 (0.46) | NR1H4PPARD | |
| SCHEMBL3710274 | 0.83 | JMJD6 (0.38) | NR1H4LMNAMAPTTHRB | |
| SCHEMBL3709692 | 0.82 | MAPT (0.44) | NR1H4HPGDLMNASMPD1MAPT | |
| SCHEMBL3702769 | 0.80 | S1PR1 (0.38) | NR1H4HPGDLMNA | |
| SCHEMBL2336634 | 0.80 | LPAR1 (0.43) | HPGDTHRB | |
| SCHEMBL3706744 | 0.80 | IP6K1 (0.43) | NR1H4HPGDLMNAMAPTMRGPRX4 | |
| SCHEMBL2332523 | 0.80 | MAPT (0.40) | HPGDLMNAMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |