Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.60 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.60 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.60 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30419995 | 1.00 | PKM (0.67) | PKMGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL4261621 | 0.89 | PKM (0.67) | PKMGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL21808846 | 0.86 | PKM (0.70) | PKMMTNR1AMTNR1BSMN1; SMN2MEN1 | |
| SCHEMBL2081979 | 0.86 | MTNR1A (0.60) | PKMGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL29444458 | 0.86 | MTNR1A (0.60) | PKMGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL5177499 | 0.85 | PKM (0.68) | PKMSMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL28117217 | 0.85 | CYP1A2 (0.70) | PKMGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL6220526 | 0.84 | PKM (0.67) | PKMGABRA1GABRB2SMN1; SMN2MEN1 | |
| SCHEMBL21808836 | 0.84 | PKM (0.67) | PKMGPR84MTNR1AMTNR1BSMN1; SMN2 | |
| SCHEMBL6600034 | 0.84 | PKM (0.67) | PKMSMN1; SMN2MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3636642-B1 | INDOLEACETIC ACID DERIVATIVES FOR USE IN THE TREATMENT OF COUGH | INST CHINESE MATERIA MEDICA CHINA ACADEMY OF CMS (CN) | 2025-12-24 | — | — | EP | disclosed |
| US-20250066386-A1 | INHIBITORS OF KRAS | BIOMEA FUSION, INC. | 2025-02-27 | — | — | US | disclosed |
| WO-2023086341-A1 | INHIBITORS OF KRAS | BIOMEA FUSION, INC. (US) | 2023-05-19 | — | — | WO | disclosed |
| EP-4026828-A1 | AUXIN-INDUCIBLE DEGRON SYSTEM KIT AND USE THEREOF | Inter-University Research Institute Corporation Research Organization of Information and Systems (JP) | 2022-07-13 | — | — | EP | disclosed |
| US-11008360-B2 | Indoleacetic acid derivative and preparation method and pharmaceutical use thereof | INSTITUTE OF CHINESE MATERIA MEDICA, CHINA ACADEMY OF CHINESE MEDICAL SCIENCES (CN) | 2021-05-18 | — | — | US | disclosed |
| EP-3636642-A1 | INDOLEACETIC ACID DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | Institute Of Chinese Materia Medica China Academy of Sciences (CN) | 2020-04-15 | — | — | EP | disclosed |
| US-20200095271-A1 | INDOLEACETIC ACID DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | INSTITUTE OF CHINESE MATERIA MEDICA, CHINA ACADEMY OF CHINESE MEDICAL SCIENCES (CN) | 2020-03-26 | — | — | US | disclosed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| EP-1581491-A1 | INDOLE DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-05 | — | — | EP | disclosed |
| EP-1581521-A1 | FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004092131-A1 | INDOLE DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-10-28 | — | — | WO | disclosed |
| WO-2004063190-A1 | FUSED HETEROCYCLIC DERIVATES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250066386-A1 | INHIBITORS OF KRAS | KRAS, NRAS, HRAS | PKM 4707/4885GABRA1 3566/4885GABRB1 3413/4885 |
| US-20200095271-A1 | INDOLEACETIC ACID DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | IDO1, IDO2, TPH1 | PKM 1938/4885GABRA1 294/4885GABRB1 573/4885 |
| US-11008360-B2 | Indoleacetic acid derivative and preparation method and pharmaceutical use thereof | IDO1, IDO2, TPH1 | PKM 1938/4885GABRA1 294/4885GABRB1 573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.