Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 12/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 3/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PKLR | P30613 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369444 | 0.76 | NPBWR1 (0.48) | NPBWR1MCHR1UCHL1 | |
| SCHEMBL370914 | 0.76 | NPBWR1 (0.48) | NPBWR1MCHR1UCHL1 | |
| SCHEMBL369974 | 0.76 | NPBWR1 (0.48) | NPBWR1MCHR1CMA1PDE1BUCHL1 | |
| SCHEMBL371091 | 0.73 | NPBWR1 (0.45) | NPBWR1MCHR1CMA1UCHL1GSK3B | |
| SCHEMBL368793 | 0.73 | NPBWR1 (0.45) | NPBWR1MCHR1UCHL1 | |
| SCHEMBL370615 | 0.71 | NPBWR1 (0.44) | NPBWR1MCHR1UCHL1 | |
| SCHEMBL27077822 | 0.71 | NPBWR1 (0.48) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL28890205 | 0.70 | NPBWR1 (0.63) | NPBWR1MCHR1CMA1 | |
| SCHEMBL190915 | 0.69 | ALDH1A1 (0.65) | CMA1GSK3AGSK3B | |
| SCHEMBL1197385 | 0.69 | NPBWR1 (0.51) | NPBWR1MCHR1CMA1UCHL1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | disclosed |