SCHEMBL3704763

SCHEMBL3704763

CC(=O)NC1(C(=O)O)CCCCC1

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FFAR3 O14843 1/20 0.39
HTT P42858 1/20 0.39
ALDH1A1 P00352 2/20 0.38
MAPT P10636 1/20 0.36
CYP2C19 P33261 1/20 0.35
CYP1A2 P05177 1/20 0.35
CNR2 P34972 4/20 0.35
L3MBTL1 Q9Y468 1/20 0.34
PYGL P06737 4/20 0.34
FABP4 P15090 3/20 0.34
FABP5 Q01469 3/20 0.34
CYP2C9 P11712 1/20 0.34
OPRM1 P35372 1/20 0.33
OPRK1 P41145 1/20 0.33
OGFRL1 Q5TC84 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1573844 0.98 FFAR3 (0.40) FFAR3HTTALDH1A1MAPTCYP2C19
SCHEMBL9613093 0.93 FFAR3 (0.40) FFAR3HTTALDH1A1CYP1A2CNR2
SCHEMBL3985967 0.88 FFAR3 (0.43) FFAR3HTTALDH1A1PYGLFABP4
SCHEMBL9594339 0.83 PYGL (0.42) ALDH1A1MAPTPYGLCYP2C9
SCHEMBL10808711 0.81 ALDH1A1 (0.40) HTTALDH1A1MAPTCYP2C19CYP1A2
SCHEMBL9595463 0.80 ALDH1A1 (0.43) ALDH1A1MAPTPYGLFABP4FABP5
SCHEMBL13448704 0.80 ALDH1A1 (0.40) HTTALDH1A1MAPTCNR2L3MBTL1
SCHEMBL10797567 0.79 ALDH1A1 (0.35) HTTALDH1A1MAPTCYP2C19CYP1A2
SCHEMBL23870441 0.79 CTSB (0.36) ALDH1A1MAPTCYP2C19CNR2L3MBTL1
SCHEMBL21547934 0.78 KDM4E (0.52) FFAR3CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2225221-A2 CARBOXYL- OR HYDROXYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2010-09-08 EP claimed
WO-2009080555-A2 CARBOXYL- OR HYDROXYL- SUBSTITUTED BENZIMIDAZOLE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2009-07-02 WO claimed
WO-2002023784-A2 CYSTEINE PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-03-21 WO claimed
WO-2021062246-A1 CRF RECEPTOR ANTAGONISTS AND METHODS OF USE NEUROCRINE BIOSCIENCES, INC. (US) 2021-04-01 WO disclosed
EP-2225221-A2 CARBOXYL- OR HYDROXYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2010-09-08 EP disclosed
WO-2009080555-A2 CARBOXYL- OR HYDROXYL- SUBSTITUTED BENZIMIDAZOLE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2009-07-02 WO disclosed
WO-2009072643-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-06-11 WO disclosed
WO-2002023784-A2 CYSTEINE PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-03-21 WO disclosed