SCHEMBL3704895

SCHEMBL3704895

CCCNc1c(C(=O)NC)cccc1-c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.44
CHRNA4 P43681 3/20 0.44
CHRNB4 P30926 2/20 0.44
CHRNA3 P32297 2/20 0.44
PLK1 P53350 1/20 0.42
GABRG2 P18507 1/20 0.41
GABRB3 P28472 1/20 0.41
GABRA2 P47869 1/20 0.41
ITGB1 P05556 1/20 0.41
ITGA4 P13612 1/20 0.41
GAA P10253 2/20 0.41
ALDH1A1 P00352 3/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
FGFR1 P11362 1/20 0.40
FGFR2 P21802 1/20 0.40
FGFR4 P22455 1/20 0.40
FGFR3 P22607 1/20 0.40
CXCR2 P25025 1/20 0.40
HNF4A P41235 1/20 0.40
LMNA P02545 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3708756 0.92 CYP2C9 (0.47) CHRNB2CHRNA4CHRNB4CHRNA3ALDH1A1
SCHEMBL3698511 0.89 CHRNB2 (0.47) CHRNB2CHRNA4CHRNB4CHRNA3PLK1
SCHEMBL3714026 0.83 CHRNB2 (0.58) CHRNB2CHRNA4CHRNB4CHRNA3PLK1
SCHEMBL29434886 0.77 HNF4A (0.66) CHRNB2CHRNA4CHRNB4CHRNA3PLK1
SCHEMBL4785901 0.77 BCAT2 (0.51) ALDH1A1LMNAHTTKDM4EHPGD
SCHEMBL3223294 0.77 CHRNB2 (0.65) CHRNB2CHRNA4CHRNB4CHRNA3GAA
SCHEMBL27573602 0.77 CHRNB2 (0.49) CHRNB2CHRNA4CHRNB4CHRNA3PLK1
SCHEMBL28085560 0.74 HNF4A (0.51) CHRNB2CHRNA4CHRNB4CHRNA3PLK1
SCHEMBL15472559 0.74 CHRNB2 (0.56) CHRNB2CHRNA4CHRNB4CHRNA3PLK1
SCHEMBL8592352 0.73 ITGB1 (0.42) GABRG2GABRB3GABRA2ITGB1ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2197835-A1 BICYCLIC ARYL AND HETEROARYL RECEPTOR MODULATORS Prosidion Limited (GB) 2010-06-23 EP disclosed
WO-2009030962-A1 BICYCLIC ARYL AND HETEROARYL RECEPTOR MODULATORS PROSIDION LIMITED (GB) 2009-03-12 WO disclosed