Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712290 | 0.92 | NR3C1 (0.38) | TP53MAPTP2RX3PTGS2KDM4E | |
| SCHEMBL3717698 | 0.91 | P2RX3 (0.38) | F10P2RX3PTGS2KDM4ESMN1; SMN2 | |
| SCHEMBL3705145 | 0.89 | TLR7 (0.35) | TP53MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL3702204 | 0.88 | TP53 (0.38) | TP53MAPTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL1247798 | 0.88 | KDM4E (0.37) | TP53MAPTF10P2RX3KDM4E | |
| SCHEMBL3709661 | 0.84 | LPAR1 (0.41) | TP53MAPTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3702549 | 0.83 | LPAR1 (0.39) | P2RX3PTGS2KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2335475 | 0.82 | KDM4E (0.39) | TP53MAPTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3701871 | 0.82 | KDM4E (0.34) | TP53MAPTF10KDM4ESMN1; SMN2 | |
| SCHEMBL3715778 | 0.81 | KDM4E (0.38) | TP53MAPTKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |