Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.37 |
| ▸ | GCG | P01275 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.32 |
| ▸ | VEGFA | P15692 | 2/20 | 0.32 |
| ▸ | FLT1 | P17948 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 3/20 | 0.31 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.31 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.31 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.31 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.31 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.31 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370503 | 0.90 | GPBAR1 (0.46) | GPBAR1PPARGMEN1CYP1A2KMT2A | |
| SCHEMBL369976 | 0.86 | GPBAR1 (0.35) | GPBAR1GCGALDH1A1GCGR | |
| SCHEMBL1389730 | 0.81 | GPBAR1 (0.41) | GPBAR1GCGPPARGEGLN1VEGFA | |
| SCHEMBL1389593 | 0.81 | GPBAR1 (0.41) | GPBAR1GCGPPARGEGLN1VEGFA | |
| SCHEMBL1389596 | 0.81 | GPBAR1 (0.41) | GPBAR1GCGPPARGEGLN1VEGFA | |
| SCHEMBL369177 | 0.80 | GPBAR1 (0.33) | GPBAR1KEAP1NFE2L2 | |
| SCHEMBL363289 | 0.78 | GPBAR1 (0.41) | GPBAR1GCGPPARGEGLN1VEGFA | |
| SCHEMBL370210 | 0.76 | GPBAR1 (0.43) | GPBAR1KDM4E | |
| SCHEMBL1389691 | 0.74 | GPBAR1 (0.39) | GPBAR1GCGPPARGEGLN1MEN1 | |
| SCHEMBL1389689 | 0.74 | GPBAR1 (0.39) | GPBAR1GCGPPARGEGLN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |