Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | IDH1 | O75874 | 4/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11549616 | 0.98 | CALM1 (0.38) | CALM1DAOSORT1PKMKMT2A | |
| SCHEMBL6209486 | 0.89 | ALDH1A1 (0.41) | CALM1DAOKMT2APOLBL3MBTL1 | |
| SCHEMBL8414683 | 0.85 | CALM1 (0.39) | CALM1DAOSORT1KMT2AMAOA | |
| SCHEMBL110859 | 0.82 | CALM1 (0.52) | CALM1DAOALDH1A1IDH1 | |
| SCHEMBL27931008 | 0.80 | CALM1 (0.50) | CALM1DAOALDH1A1IDH1 | |
| SCHEMBL28831761 | 0.80 | CALM1 (0.50) | CALM1DAOALDH1A1IDH1 | |
| Hydrochloric Acid SCHEMBL28817569 | 0.80 | CALM1 (0.50) | CALM1ALDH1A1 | |
| SCHEMBL2333440 | 0.76 | CALM1 (0.46) | CALM1KMT2AL3MBTL1ALDH1A1HPGD | |
| SCHEMBL1399903 | 0.75 | ALDH1A1 (0.50) | CALM1KMT2AL3MBTL1ALDH1A1HPGD | |
| SCHEMBL2585502 | 0.73 | CALM1 (0.42) | CALM1KMT2AMAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291327-A2 | Aryl-substituted naphthalene, benzoxepine, benzazepine and benzocycloheptene derivatives | SCHERING CORPORATION (US) | 1988-11-17 | — | — | EP | claimed |
| EP-2807172-A1 | PYRIMIDOOXAZOCINE DERIVATIVES AS MTOR - INHIBITORS | SANOFI (FR) | 2014-12-03 | — | — | EP | disclosed |
| WO-2013111106-A1 | PYRIMIDOOXAZOCINE DERIVATIVES AS MTOR - INHIBITORS | SANOFI (FR) | 2013-08-01 | — | — | WO | disclosed |
| EP-2200962-A1 | BENZOCYCLOHEPTENE DERIVATIVES AS ESTROGENS HAVING SELECTIVE ACTIVITY | Bayer Schering Pharma Aktiengesellschaft (DE) | 2010-06-30 | — | — | EP | disclosed |
| US-20090099250-A1 | BENZOCYCLOHEPTENE DERIVATIVES AS ESTROGENS HAVING SELECTIVE ACTIVITY | BAYER SCHERING PHARMA AG (DE) | 2009-04-16 | — | — | US | disclosed |
| WO-2009047343-A1 | BENZOCYCLOHEPTENE DERIVATIVES AS ESTROGENS HAVING SELECTIVE ACTIVITY | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-04-16 | — | — | WO | disclosed |
| EP-2048126-A1 | Benzocycloheptane derivatives as selectively active oestrogens | Bayer Schering Pharma AG (DE) | 2009-04-15 | — | — | EP | disclosed |
| EP-1278729-A1 | BENZOSUBERONYLPIPERIDINE COMPOUNDS AS ANALGESICS | GlaxoSmithKline S.p.A. (IT) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083454-A1 | BENZOSUBERONYLPIPERIDINE COMPOUNDS AS ANALGESICS | GLAXOSMITHKLINE S.P.A. (IT) | 2001-11-08 | — | — | WO | disclosed |
| EP-0291327-A2 | Aryl-substituted naphthalene, benzoxepine, benzazepine and benzocycloheptene derivatives | SCHERING CORPORATION (US) | 1988-11-17 | — | — | EP | disclosed |
| US-4154852-A | ANTIDEPRESSANTS | ROUSSEL UCLAF (FR) | 1979-05-15 | — | — | US | disclosed |
| US-4148919-A | 7-Amino-6,7-dihydro [5H]benzocycloheptene derivatives | ROUSSEL UCLAF (FR) | 1979-04-10 | — | — | US | disclosed |
| US-4117164-A | ANTIDEPRESSANTS | ROUSSEL UCLAF (FR) | 1978-09-26 | — | — | US | disclosed |
| US-4091115-A | ANTIDEPRESSANTS | ROUSSEL UCLAF (FR) | 1978-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099250-A1 | BENZOCYCLOHEPTENE DERIVATIVES AS ESTROGENS HAVING SELECTIVE ACTIVITY | CYP19A1, HSD17B11, CYP21A2 | CALM1 4694/4885DAO 2316/4885SORT1 4406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.