Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 12/20 | 0.44 |
| ▸ | THRA | P10827 | 9/20 | 0.44 |
| ▸ | RORC | P51449 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3703153 | 0.94 | THRB (0.45) | THRBTHRARORC | |
| SCHEMBL3713108 | 0.92 | THRB (0.41) | THRBTHRARORC | |
| SCHEMBL3710974 | 0.91 | THRB (0.42) | THRBTHRARORCALDH1A1 | |
| SCHEMBL3712010 | 0.90 | NR3C1 (0.46) | THRBTHRARORC | |
| SCHEMBL3709210 | 0.88 | THRB (0.41) | THRBTHRARORC | |
| SCHEMBL3705224 | 0.88 | THRB (0.43) | THRBTHRARORC | |
| SCHEMBL3706682 | 0.87 | THRB (0.39) | THRBTHRARORC | |
| SCHEMBL3710607 | 0.87 | THRB (0.42) | THRBTHRARORC | |
| SCHEMBL3708836 | 0.86 | THRB (0.50) | THRBTHRARORC | |
| SCHEMBL3714503 | 0.85 | LMNA (0.47) | THRBTHRARORCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |