Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 6/20 | 0.45 |
| ▸ | THRA | P10827 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710238 | 0.94 | LMNA (0.46) | LMNAKMT2AMEN1MAPTNPSR1 | |
| SCHEMBL3708836 | 0.87 | THRB (0.50) | THRBTHRARORC | |
| SCHEMBL3703153 | 0.86 | THRB (0.45) | THRBTHRARORC | |
| SCHEMBL3705224 | 0.86 | THRB (0.43) | LMNAMAPTNPSR1THRBTHRA | |
| SCHEMBL3707754 | 0.85 | THRB (0.44) | THRBTHRAALDH1A1RORC | |
| SCHEMBL3710607 | 0.85 | THRB (0.42) | LMNATHRBTHRATP53RORC | |
| SCHEMBL3710974 | 0.84 | THRB (0.42) | LMNAMAPTTHRBTHRATSHR | |
| SCHEMBL3712010 | 0.84 | NR3C1 (0.46) | THRBTHRARORC | |
| SCHEMBL3706713 | 0.84 | THRB (0.41) | KMT2AMEN1MAPTNPSR1THRB | |
| SCHEMBL3707858 | 0.84 | RORC (0.44) | THRBTHRATP53RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |