Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 9/20 | 0.42 |
| ▸ | THRA | P10827 | 7/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712010 | 0.93 | NR3C1 (0.46) | THRBTHRANR3C1RORCHTT | |
| SCHEMBL3703153 | 0.92 | THRB (0.45) | THRBTHRANR3C1RORC | |
| SCHEMBL3709210 | 0.92 | THRB (0.41) | THRBTHRANR3C1RORCMAPT | |
| SCHEMBL3707754 | 0.91 | THRB (0.44) | THRBTHRARORCALDH1A1 | |
| SCHEMBL3705224 | 0.86 | THRB (0.43) | THRBTHRANR3C1RORCKDM4E | |
| SCHEMBL3706682 | 0.86 | THRB (0.39) | THRBTHRARORCMAPTLMNA | |
| SCHEMBL3710607 | 0.86 | THRB (0.42) | THRBTHRANR3C1RORCLMNA | |
| SCHEMBL3713108 | 0.85 | THRB (0.41) | THRBTHRARORCMCHR1 | |
| SCHEMBL3708836 | 0.85 | THRB (0.50) | THRBTHRANR3C1RORC | |
| SCHEMBL3714503 | 0.84 | LMNA (0.47) | THRBTHRARORCKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |