Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.39 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.39 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711587 | 0.93 | DRD3 (0.41) | LMNAPIK3CAPIK3CBHTR4MAPT | |
| SCHEMBL3716892 | 0.89 | HTR4 (0.43) | LMNAALDH1A1KDM4EPIK3CAPIK3CB | |
| SCHEMBL3711915 | 0.88 | PIK3CA (0.53) | LMNAALDH1A1PIK3CAPIK3CBKMT2A | |
| SCHEMBL3714245 | 0.86 | KDM4E (0.51) | LMNAALDH1A1KDM4EPIK3CAPIK3CB | |
| SCHEMBL3716189 | 0.83 | LMNA (0.46) | LMNAALDH1A1KDM4EPIK3CAPIK3CB | |
| SCHEMBL20206898 | 0.83 | LMNA (0.46) | LMNAALDH1A1KDM4EPIK3CAPIK3CB | |
| SCHEMBL3710077 | 0.82 | LMNA (0.41) | LMNAALDH1A1KDM4EPIK3CAPIK3CB | |
| SCHEMBL3716897 | 0.82 | KDM4E (0.47) | LMNAALDH1A1KDM4EPIK3CAPIK3CB | |
| SCHEMBL1579188 | 0.81 | PIK3CA (0.44) | LMNAALDH1A1KDM4EPIK3CAPIK3CB | |
| SCHEMBL1579169 | 0.80 | PIK3CA (0.58) | ALDH1A1KDM4EPIK3CAPIK3CBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |