Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.41 |
| ▸ | HTR2A | P28223 | 6/20 | 0.41 |
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 6/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710050 | 0.93 | LMNA (0.43) | PIK3CAPIK3CBMAPTLMNAHTR4 | |
| SCHEMBL3716892 | 0.87 | HTR4 (0.43) | DRD3HTR2AHTR1APIK3CAPIK3CB | |
| SCHEMBL3711915 | 0.86 | PIK3CA (0.53) | PIK3CAPIK3CBMAPTLMNA | |
| SCHEMBL3714245 | 0.84 | KDM4E (0.51) | PIK3CAPIK3CBMAPTLMNA | |
| SCHEMBL3716189 | 0.81 | LMNA (0.46) | PIK3CAPIK3CBLMNA | |
| SCHEMBL20206898 | 0.81 | LMNA (0.46) | PIK3CAPIK3CBLMNA | |
| SCHEMBL3710077 | 0.80 | LMNA (0.41) | DRD3PIK3CAPIK3CBLMNADRD2 | |
| SCHEMBL3716897 | 0.80 | KDM4E (0.47) | PIK3CAPIK3CBMAPTLMNA | |
| SCHEMBL1579188 | 0.79 | PIK3CA (0.44) | PIK3CAPIK3CBMAPTLMNA | |
| SCHEMBL1579169 | 0.78 | PIK3CA (0.58) | PIK3CAPIK3CBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |