Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710050 | 0.89 | LMNA (0.43) | HTR4PIK3CAPIK3CBFGFR1LMNA | |
| SCHEMBL3711587 | 0.87 | DRD3 (0.41) | HTR4PIK3CAPIK3CBSLC29A1HTR1A | |
| SCHEMBL3711915 | 0.87 | PIK3CA (0.53) | PIK3CAPIK3CBLMNAALDH1A1KMT2A | |
| SCHEMBL3714245 | 0.85 | KDM4E (0.51) | PIK3CAPIK3CBLMNAALDH1A1KDM4E | |
| SCHEMBL3716189 | 0.82 | LMNA (0.46) | PIK3CAPIK3CBLMNAALDH1A1KDM4E | |
| SCHEMBL20206898 | 0.82 | LMNA (0.46) | PIK3CAPIK3CBLMNAALDH1A1KDM4E | |
| SCHEMBL3710077 | 0.81 | LMNA (0.41) | PIK3CAPIK3CBDRD3LMNAALDH1A1 | |
| SCHEMBL981616 | 0.81 | HTR4 (0.40) | HTR4HDAC6MAP4K4HTR1AHTR2A | |
| SCHEMBL3716897 | 0.81 | KDM4E (0.47) | PIK3CAPIK3CBLMNAALDH1A1KDM4E | |
| SCHEMBL1579188 | 0.80 | PIK3CA (0.44) | PIK3CAPIK3CBLMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |