Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP4 | P49662 | 1/20 | 0.40 |
| ▸ | CASP5 | P51878 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714245 | 0.85 | KDM4E (0.51) | LMNAAURKAKDM4EMEN1USP2 | |
| SCHEMBL3710050 | 0.82 | LMNA (0.43) | LMNAAURKAKDM4EMEN1USP2 | |
| SCHEMBL3716892 | 0.81 | HTR4 (0.43) | LMNAAURKAKDM4EMEN1USP2 | |
| SCHEMBL3711915 | 0.80 | PIK3CA (0.53) | LMNAAURKAALDH1A1KMT2APIK3CA | |
| SCHEMBL3711587 | 0.80 | DRD3 (0.41) | LMNADRD2DRD3PIK3CAPIK3CB | |
| SCHEMBL3716189 | 0.78 | LMNA (0.46) | LMNAKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL20206898 | 0.78 | LMNA (0.46) | LMNAKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL3711790 | 0.77 | LMNA (0.50) | LMNAKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL3716897 | 0.76 | KDM4E (0.47) | LMNAKDM4EALDH1A1PIK3CAPIK3CB | |
| Hydrochloric Acid SCHEMBL3281624 | 0.76 | LMNA (0.52) | LMNAKDM4EMEN1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |