Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 3/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827151 | 0.76 | METAP2 (0.37) | METAP2METAP1NPY5R | |
| SCHEMBL7574497 | 0.76 | METAP2 (0.37) | METAP2METAP1NPY5R | |
| SCHEMBL4241036 | 0.76 | METAP2 (0.37) | METAP2METAP1NPY5R | |
| SCHEMBL4069549 | 0.71 | METAP2 (0.49) | METAP2METAP1GRIN2BNPY5RCSF1R | |
| SCHEMBL3710333 | 0.70 | CDK2 (0.41) | TSHRMAPTSMN1; SMN2TAAR1AGTR1 | |
| SCHEMBL434619 | 0.68 | GAA (0.53) | METAP2METAP1GRIN2BNPY5RTSHR | |
| SCHEMBL8332576 | 0.67 | RAB9A (0.54) | METAP2METAP1GRIN2BMAPTSMN1; SMN2 | |
| SCHEMBL5301105 | 0.66 | NOS3 (0.45) | TSHRMAPTMAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL5440113 | 0.66 | KDM4C (0.47) | METAP2METAP1GRIN2BNPY5R | |
| SCHEMBL1444127 | 0.66 | TSHR (0.65) | TSHRMAPTCSF1RTP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203451-A2 | SUBSTITUTED 6-(ALKYLBENZYLAMINO)PURINE DERIVATIVES FOR USE AS CYTOKININ RECEPTOR ANTAGONISTS AND PREPARATIONS CONTAINING THESE DERIVATIVES | Univerzita palackeho V Olomouci (CZ) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009043320-A2 | SUBSTITUTED 6-(ALKYLBENZYLAMINO)PURINE DERIVATIVES FOR USE AS CYTOKININ RECEPTOR ANTAGONISTS AND PREPARATIONS CONTAINING THESE DERIVATIVES | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2009-04-09 | — | — | WO | disclosed |