Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827151 | 0.83 | METAP2 (0.37) | METAP2METAP1ENPP1NPY5R | |
| SCHEMBL4241036 | 0.83 | METAP2 (0.37) | METAP2METAP1NPY5R | |
| SCHEMBL10910376 | 0.79 | — | — | |
| SCHEMBL3710330 | 0.76 | METAP2 (0.40) | METAP2METAP1NPY5R | |
| SCHEMBL7072867 | 0.72 | NUDT1 (0.49) | METAP2METAP1ENPP1NPY5R | |
| SCHEMBL1445584 | 0.72 | NUDT1 (0.49) | METAP2METAP1ENPP1NPY5R | |
| SCHEMBL1079071 | 0.71 | METAP2 (0.41) | METAP2METAP1ENPP1NPY5R | |
| SCHEMBL434033 | 0.68 | METAP2 (0.44) | METAP2METAP1ENPP1NPY5R | |
| SCHEMBL2563782 | 0.68 | KMT2A (0.50) | METAP2METAP1ENPP1 | |
| SCHEMBL432903 | 0.68 | ALDH1A1 (0.40) | METAP2METAP1ENPP1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538332-A1 | POLYCYCLIC GUANINE DERIVATIVES. | SCHERING CORP (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |