SCHEMBL434619

SCHEMBL434619

c1ccc(Cc2nc3ncncc3[nH]2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.53
METAP2 P50579 1/20 0.49
METAP1 P53582 1/20 0.49
PKM P14618 2/20 0.46
TSHR P16473 1/20 0.46
KDM4E B2RXH2 1/20 0.44
MAPT P10636 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
PNP P00491 1/20 0.43
KMT2A Q03164 1/20 0.42
GRIN2B Q13224 2/20 0.41
GRIN1 Q05586 1/20 0.41
RIPK1 Q13546 1/20 0.41
ERBB2 P04626 2/20 0.40
EGFR P00533 1/20 0.40
TAAR1 Q96RJ0 1/20 0.40
GSK3B P49841 1/20 0.40
NPY5R Q15761 1/20 0.39
HTR6 P50406 1/20 0.39
HPGDS O60760 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8332576 0.86 RAB9A (0.54) METAP2METAP1MAPTGRIN2BGSK3B
SCHEMBL10602607 0.80 METAP2 (0.48) METAP2METAP1KDM4EGRIN2BERBB2
SCHEMBL5493570 0.80 METAP2 (0.45) GAAMETAP2METAP1PKMKDM4E
SCHEMBL10303928 0.79 CYP17A1 (0.43) METAP2METAP1PKMGRIN2B
SCHEMBL27886361 0.78 GAA (0.53) GAAPKMTSHRKDM4EMAPT
SCHEMBL8806229 0.78 GAA (0.60) GAAMETAP2METAP1PKMTSHR
SCHEMBL18060062 0.77 HDAC6 (0.42) GAAPKMKDM4EMAPTTDP1
SCHEMBL1034656 0.77 GAA (0.51) GAAPKMTSHRKDM4EMAPT
SCHEMBL27678532 0.77 GAA (0.51) GAAPKMTSHRKDM4EMAPT
SCHEMBL5440113 0.76 KDM4C (0.47) METAP2METAP1GRIN2BNPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1178 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118805676-A Rapid training method for bird's nest fruits 海南希源生态农业股份有限公司 2024-10-22 CN claimed
CN-117099578-A Nutritional propagation method of onion male sterile plant 兰州龙腾农业科技有限公司 2023-11-24 CN claimed
EP-3131914-B1 3'-SUBSTITUTED METHYL OR ALKYNYL NUCLEOSIDES FOR THE TREATMENT OF HCV IDENIX PHARMACEUTICALS LLC (US) 2023-05-10 EP claimed
CN-113998653-A Culture medium subpackaging device and preparation method thereof 广西壮族自治区农业科学院 2022-02-01 CN claimed
CN-112913690-A Peony in-vitro regeneration method 四川农业大学 2021-06-08 CN claimed
US-10202411-B2 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV IDENIX PHARMACEUTICALS LLC (US) 2019-02-12 US claimed
CN-109197582-A A kind of culture medium of golden flower tea callus bud induction 罗甸县五湖生态农业旅游开发有限责任公司 2019-01-15 CN claimed
CN-108935094-A A kind of bletilla striata cultural method rapidly and efficiently 贵州发来地农业科技有限公司 2018-12-07 CN claimed
CN-108935093-A A kind of bletilla striata tissue culture method primary 贵州发来地农业科技有限公司 2018-12-07 CN claimed
CN-108617504-A A kind of special Initial culture base of candidum tissue culturing seedling and preparation method thereof 黄振忠 2018-10-09 CN claimed
CN-1453251-A Acid liquid fertilizer for drip irrigation and its prepn INST PROCESS ENG CAS (CN) 2003-11-05 CN claimed
EP-1335920-A2 SMALL MOLECULE COMPOSITIONS FOR BINDING TO HSP90 Sloan-Kettering Institute For Cancer Research (US) 2003-08-20 EP claimed
US-6518425-B1 A process for producing a 1,3-oxathiolane nucleoside comprising reacting a 5-halo-2-protected-oxymethyl-1,3-oxathiolane with a silylated purine or pyrimidine without the addition of a Lewis acid or an additional base to the reaction EMORY UNIVERSITY 2003-02-11 US claimed
US-20030013880-A1 Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers APOTEX PHARMACHEM INC (CA) 2003-01-16 US claimed
WO-2002036075-A2 SMALL MOLECULE COMPOSITIONS FOR BINDING TO HSP90 SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2002-05-10 WO claimed
CN-1085042-A Biocide for protecting cotton bolls and eliminating fusarium wilt of cotton WANG LIANFANG (CN) 1994-04-13 CN claimed
EP-0562009-A4 ENANTIOMERICALLY PURE -G(B)-D-(-)-DIOXOLANE-NUCLEOSIDES 1993-11-24 EP claimed
EP-0562009-A1 ENANTIOMERICALLY PURE $g(b)-D-(-)-DIOXOLANE-NUCLEOSIDES THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 1993-09-29 EP claimed
WO-1992010496-A1 ENANTIOMERICALLY PURE β-L-(-)-1,3-OXATHIOLANE NUCLEOSIDES UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 1992-06-25 WO claimed
WO-1992010497-A1 ENANTIOMERICALLY PURE β-D-(-)-DIOXOLANE-NUCLEOSIDES UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 1992-06-25 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030013880-A1 Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers SLC29A1, NUDT1, SLC28A1 GAA 1466/4885METAP2 1203/4885METAP1 572/4885
US-10202411-B2 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV RB1, NSUN2, METTL3 GAA 2394/4885METAP2 1396/4885METAP1 2385/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.