Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ACP1 | P24666 | 3/20 | 0.48 |
| ▸ | PDE5A | O76074 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3676959 | 0.78 | RAB9A (0.49) | KDM4ELMNATDP1GAAMEN1 | |
| SCHEMBL3718194 | 0.76 | ADORA1 (0.45) | KDM4ELMNATDP1KMT2AACP1 | |
| SCHEMBL20419261 | 0.75 | MEN1 (0.50) | LMNAL3MBTL1GAAMEN1KMT2A | |
| SCHEMBL1068979 | 0.75 | CARM1 (0.49) | KDM4ELMNAL3MBTL1TDP1GAA | |
| SCHEMBL13950894 | 0.75 | KDM4E (0.78) | KDM4ELMNAL3MBTL1TDP1GAA | |
| SCHEMBL30598742 | 0.74 | L3MBTL1 (0.60) | KDM4ELMNAL3MBTL1TDP1GAA | |
| SCHEMBL1372014 | 0.74 | L3MBTL1 (0.60) | KDM4ELMNAL3MBTL1TDP1GAA | |
| SCHEMBL24590007 | 0.73 | KDM4E (0.75) | KDM4ELMNAL3MBTL1TDP1GAA | |
| SCHEMBL22769176 | 0.73 | KDM4E (0.75) | KDM4ELMNAL3MBTL1TDP1GAA | |
| SCHEMBL22769174 | 0.73 | KDM4E (0.75) | KDM4ELMNAL3MBTL1TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391623-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010088177-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-08-05 | — | — | WO | disclosed |