Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PRNP | P04156 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ECE1 | P42892 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15055415 | 0.78 | KDM4E (0.33) | CYP2C19L3MBTL1KDM4EKDM5CEGLN1 | |
| SCHEMBL4223239 | 0.78 | SMN1; SMN2 (0.46) | CYP2C19POLBL3MBTL1KDM4EKDM5C | |
| SCHEMBL21110596 | 0.78 | ADRA1A (0.36) | CYP2C19POLBL3MBTL1KDM4EKDM5C | |
| SCHEMBL1935273 | 0.75 | ALDH1A1 (0.39) | CYP2C19POLBL3MBTL1KDM4EKDM5C | |
| SCHEMBL4229696 | 0.73 | CYP2D6 (0.39) | CYP2C19POLBKDM4EKDM5CEGLN1 | |
| SCHEMBL1067952 | 0.73 | CYP1A2 (0.39) | CYP2C19CYP1A2POLBL3MBTL1KDM4E | |
| SCHEMBL2438348 | 0.73 | CYP2D6 (0.36) | CYP2C19POLBKDM4CECE1CYP2D6 | |
| SCHEMBL3713026 | 0.71 | L3MBTL1 (0.39) | CYP2C19CYP1A2POLBL3MBTL1KDM4E | |
| SCHEMBL6635776 | 0.71 | L3MBTL1 (0.46) | CYP2C19CYP1A2L3MBTL1KDM4ELMNA | |
| SCHEMBL4040747 | 0.70 | LMNA (0.46) | CYP2C19POLBKDM4EKDM5CEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |