Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362720 | 0.83 | SORT1 (0.33) | SORT1SMN1; SMN2KMT2ANPSR1TSHR | |
| SCHEMBL364575 | 0.82 | KCNN4 (0.40) | SORT1NPSR1UHRF1MAPK1KDM4E | |
| SCHEMBL364536 | 0.77 | SORT1 (0.35) | SORT1TSHRALDH1A1 | |
| SCHEMBL363549 | 0.77 | NPC1 (0.34) | SORT1SMN1; SMN2NPSR1ALDH1A1MAPK1 | |
| SCHEMBL364193 | 0.77 | NPC1 (0.34) | SORT1SMN1; SMN2NPSR1ALDH1A1MAPK1 | |
| SCHEMBL362869 | 0.77 | TRPV1 (0.38) | SORT1SMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL363211 | 0.77 | NPC1 (0.34) | SORT1SMN1; SMN2NPSR1ALDH1A1MAPK1 | |
| SCHEMBL364776 | 0.74 | POLB (0.35) | SORT1MEN1KMT2AALDH1A1UHRF1 | |
| SCHEMBL363061 | 0.73 | KCNN4 (0.34) | SORT1NPSR1MAPK1KDM4E | |
| SCHEMBL363897 | 0.72 | AR (0.36) | SMN1; SMN2MEN1KMT2ANPSR1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |