Purine

Purine

SCHEMBL37120

[NaH].c1ncc2[nH]cnc2n1

nearest known ligand 0.45

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.45
KDM4E B2RXH2 1/20 0.45
METAP2 P50579 1/20 0.39
METAP1 P53582 1/20 0.39
PI4KA P42356 2/20 0.38
PI4K2B Q8TCG2 2/20 0.38
PI4K2A Q9BTU6 2/20 0.38
PI4KB Q9UBF8 2/20 0.38
LRRK2 Q5S007 2/20 0.38
LMNA P02545 2/20 0.38
DRD3 P35462 1/20 0.38
XDH P47989 1/20 0.38
G6PD P11413 1/20 0.36
CDK2 P24941 3/20 0.36
RXFP1 Q9HBX9 1/20 0.36
PDPK1 O15530 2/20 0.34
TP53 P04637 2/20 0.34
CHEK1 O14757 1/20 0.34
AURKA O14965 1/20 0.34
CHEK2 O96017 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Purine SCHEMBL2120554 0.98 ALDH1A1 (0.47) ALDH1A1KDM4EMETAP2METAP1PI4KA
Purine SCHEMBL29703771 0.98 ALDH1A1 (0.47) ALDH1A1KDM4EMETAP2METAP1PI4KA
Purine SCHEMBL6421380 0.98 ALDH1A1 (0.47) ALDH1A1KDM4EMETAP2METAP1PI4KA
Purine SCHEMBL29365913 0.98
Purine SCHEMBL3158 0.98
Purine SCHEMBL30862524 0.98
Purine SCHEMBL7787140 0.95 ALDH1A1 (0.45) ALDH1A1KDM4EMETAP2METAP1PI4KA
Purine SCHEMBL31255906 0.95 ALDH1A1 (0.45) ALDH1A1KDM4EMETAP2METAP1PI4KA
Purine SCHEMBL712798 0.95 ALDH1A1 (0.45) ALDH1A1KDM4EMETAP2METAP1PI4KA
Purine SCHEMBL6438164 0.95 ALDH1A1 (0.45) ALDH1A1KDM4EMETAP2METAP1PI4KA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109294976-A A kind of serum free medium for supporting HEK293 cell suspension cultures 王晓柯 2019-02-01 CN claimed
CN-105377238-B method for treating arthritis 台湾微脂体股份有限公司 2018-09-07 CN claimed
CN-107236708-A A kind of serum free medium for supporting HeLa cell attachment cultures 王晓柯 2017-10-10 CN claimed
EP-0304004-B1 Process for the production of sodium purines BOEHRINGER INGELHEIM KG (DE) 1993-11-03 EP claimed
WO-2020192302-A1 PYRIMIDINE-CONTAINING TRI-SUBSTITUTED IMIDAZOLE COMPOUND AND APPLICATION THEREOF 广州必贝特医药技术有限公司 2020-10-01 WO disclosed
CN-110352071-A Lipidic nanoparticles mRNA vaccine 库瑞瓦格股份公司 2019-10-18 CN disclosed
CN-109843921-A Programmed death 1 ligand 1(PD-L1) binding proteins and methods of use thereof 艾欧凡斯生物治疗公司 2019-06-04 CN disclosed
CN-109790143-A Amine-linked C for target protein degradation3-glutarimide solution stator body C4医药公司 2019-05-21 CN disclosed
CN-109641874-A C for target protein degradation3The glutarimide degron body of carbon connection C4医药公司 2019-04-16 CN disclosed
CN-109562113-A Spirocyclo-rongeur for target protein degradation C4医药公司 2019-04-02 CN disclosed
CN-109562107-A Heterocyclic degrading ligand for target protein degradation C4医药公司 2019-04-02 CN disclosed
CN-109563154-A Anti- Padua factors IX antibody 拜科赛尔塔公司 2019-04-02 CN disclosed
WO-2000064918-A1 METHOD FOR THE PRODUCTION OF 2-CHLORO-2'-DEOXYADENOSINE (CLADRIBINE) AND ITS 3,5-DI-O-p-TOLUOYL DERIVATIVE STERRENBELD BIOTECHNOLOGIE NORTH AMERICA, INC. (US) 2000-11-02 WO disclosed
CN-1040114-C Stereoselective glycosylation process LILLY CO ELI (US) 1998-10-07 CN disclosed
US-5532225-A TREATMENT OF HERPES VIRUS SRI INTERNATIONAL (US) 1996-07-02 US disclosed
CN-1085560-A Stereoselective glycosylation process LILLY CO ELI (US) 1994-04-20 CN disclosed
WO-1994003466-A1 ACYCLIC PURINE PHOSPHONATE NUCLEOTIDE ANALOGS AS ANTIVIRAL AGENTS, AND RELATED SYNTHETIC METHODS SRI INTERNATIONAL (US) 1994-02-17 WO disclosed
EP-0304004-B1 Process for the production of sodium purines BOEHRINGER INGELHEIM KG (DE) 1993-11-03 EP disclosed
EP-0304004-A1 Process for the production of sodium purines BOEHRINGER INGELHEIM KG (DE) 1989-02-22 EP disclosed
EP-0304004-A1 Process for the production of sodium purines BOEHRINGER INGELHEIM KG (DE) 1989-02-22 EP disclosed