Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.51 |
| ▸ | SCN4A | P35499 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2987920 | 0.85 | PRSS1 (0.51) | PRSS1PRSS2PRSS3EGFRERBB2 | |
| SCHEMBL16728552 | 0.83 | CA12 (0.46) | ALDH1A1KMT2AKDM4EHSD17B10LMNA | |
| SCHEMBL27490729 | 0.81 | ALDH1A1 (0.49) | PRSS1PRSS2PRSS3EGFRERBB2 | |
| SCHEMBL27314977 | 0.80 | PRSS1 (0.53) | PRSS1PRSS2PRSS3EGFRERBB2 | |
| SCHEMBL9048057 | 0.80 | SCN4A (0.50) | PRSS1PRSS2PRSS3SCN4AALDH1A1 | |
| SCHEMBL10356118 | 0.80 | LTA4H (0.49) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL671557 | 0.80 | LTA4H (0.49) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL27477537 | 0.80 | LTA4H (0.49) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL43233 | 0.79 | PRSS1 (0.67) | PRSS1PRSS2PRSS3EGFRERBB2 | |
| SCHEMBL44568 | 0.79 | PRSS1 (0.62) | PRSS1PRSS2PRSS3EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673974-B2 | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors | NOVARTIS AG (CH) | 2014-03-18 | — | — | US | disclosed |
| EP-2640690-A1 | SUBSTITUTED AMINO BISPHENYL PENTANOIC ACID DERIVATIVES AS NEP INHIBITORS | Novartis AG (CH) | 2013-09-25 | — | — | EP | disclosed |
| CN-103201257-A | Substituted amino bisphenyl pentanoic acid derivatives as nep inhibitors | NOVARTIS AG | 2013-07-10 | — | — | CN | disclosed |
| WO-2012065956-A1 | SUBSTITUTED AMINO BISPHENYL PENTANOIC ACID DERIVATIVES AS NEP INHIBITORS | NOVARTIS AG (CH) | 2012-05-24 | — | — | WO | disclosed |
| US-20120122977-A1 | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors | NOVARTIS AG (CH) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122977-A1 | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors | REN, MME, AGTR1 | PRSS1 47/4885PRSS2 418/4885PRSS3 216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.