Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.34 |
| ▸ | SYK | P43405 | 3/20 | 0.34 |
| ▸ | CCR5 | P51681 | 4/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722179 | 0.80 | SMN1; SMN2 (0.42) | MEN1KMT2ASYK | |
| SCHEMBL3718972 | 0.75 | CYP3A4 (0.43) | MEN1CYP3A4KMT2ATGFBR1SYK | |
| SCHEMBL3715143 | 0.71 | MAP3K5 (0.51) | SYKMAPK8MAPK9JAK3 | |
| SCHEMBL3716217 | 0.70 | SMN1; SMN2 (0.44) | MEN1KMT2A | |
| SCHEMBL2713930 | 0.69 | OPRM1 (0.39) | CYP3A4TGFBR1SYKCCR5CHEK1 | |
| SCHEMBL3718752 | 0.69 | SYK (0.44) | SYKMAPK8MAPK9JAK3 | |
| SCHEMBL25634102 | 0.68 | SYK (0.53) | SYKMAPK8MAPK9 | |
| SCHEMBL17083657 | 0.68 | SYK (0.53) | SYKMAPK8MAPK9 | |
| SCHEMBL12904538 | 0.67 | JAK2 (0.55) | SYKJAK3 | |
| SCHEMBL914058 | 0.67 | VNN1 (0.41) | SYKMAPK8MAPK9OPRM1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |