Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 12/20 | 0.46 |
| ▸ | CTSK | P43235 | 11/20 | 0.46 |
| ▸ | CTSB | P07858 | 3/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3651290 | 0.84 | CTSS (0.46) | CTSSCTSKCTSBCTSLSYK | |
| SCHEMBL3654576 | 0.84 | CTSS (0.46) | CTSSCTSKCTSBCTSLSYK | |
| SCHEMBL5170834 | 0.83 | CTSS (0.61) | CTSSCTSKCTSBCTSLSYK | |
| SCHEMBL2002111 | 0.78 | CTSS (0.53) | CTSSCTSKCTSBCTSLSYK | |
| SCHEMBL28498781 | 0.76 | CTSS (0.43) | CTSSCTSKCTSBCTSLSYK | |
| SCHEMBL2809280 | 0.76 | CTSK (0.48) | CTSSCTSKCTSBCTSLACACB | |
| SCHEMBL2809279 | 0.76 | CTSK (0.48) | CTSSCTSKCTSBCTSLACACB | |
| SCHEMBL3660901 | 0.75 | CTSS (0.48) | CTSSCTSKCTSBCTSL | |
| SCHEMBL21523879 | 0.75 | NPC1 (0.64) | NR1H4NPC1RAB9A | |
| SCHEMBL7517658 | 0.73 | ACACB (0.59) | NR1H4ACACBNPC1RAB9ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010108059-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF THE HISTAMINE H4 RECEPTOR | INCYTE CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |