Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 8/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | MLNR | O43193 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.31 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.31 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.31 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.31 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.31 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.31 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.31 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.31 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.31 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oleandomycin SCHEMBL29684259 | 0.86 | CYP3A4 (1.00) | CYP3A4LMNAUSP2ABCB1KCNH2 | |
| Oleandomycin SCHEMBL10028439 | 0.86 | CYP3A4 (1.00) | CYP3A4LMNAUSP2ABCB1KCNH2 | |
| Oleandomycin SCHEMBL3716 | 0.86 | CYP3A4 (1.00) | CYP3A4LMNAUSP2ABCB1KCNH2 | |
| Oleandomycin SCHEMBL3717 | 0.86 | CYP3A4 (1.00) | CYP3A4LMNAUSP2ABCB1KCNH2 | |
| Oleandomycin SCHEMBL9807053 | 0.85 | CYP3A4 (0.99) | CYP3A4LMNAUSP2ABCB1KCNH2 | |
| Oleandomycin SCHEMBL950913 | 0.84 | CYP3A4 (0.96) | CYP3A4LMNAUSP2ABCB1KCNH2 | |
| Oleandomycin SCHEMBL285338 | 0.83 | CYP3A4 (1.00) | CYP3A4LMNAUSP2ABCB1KCNH2 | |
| Oleandomycin SCHEMBL5033021 | 0.83 | CYP3A4 (1.00) | CYP3A4LMNAUSP2ABCB1KCNH2 | |
| SCHEMBL2619140 | 0.80 | CYP3A4 (0.55) | CYP3A4LMNAUSP2ABCB1 | |
| SCHEMBL3439708 | 0.78 | CYP3A4 (0.51) | CYP3A4LMNAUSP2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013619-B1 | METHODS FOR USING HUMAN EMBRYONIC STEM CELLS TO EVALUATE TOXICITY OF PHARMACEUTICAL COMPOUNDS & OTHER CHEMICALS | WISCONSIN ALUMNI RES FOUND (US) | 2017-10-11 | — | — | EP | disclosed |
| US-20140255969-A1 | REAGENTS AND METHODS FOR USING HUMAN EMBRYONIC STEM CELLS TO EVALUATE TOXICITY OF PHARMACEUTICAL COMPOUNDS AND OTHER CHEMICALS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-09-11 | — | — | US | disclosed |
| US-8703483-B2 | Reagents and methods for using human embryonic stem cells to evaluate toxicity of pharmaceutical compounds and other chemicals | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-20070248947-A1 | Reagents and Methods for Using Human Embryonic Stem Cells to Evaluate Toxicity of Pharmaceutical Compounds and Other Chemicals | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-10-25 | — | — | US | disclosed |