Oleandomycin

Oleandomycin

SCHEMBL285338

CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H](C)C[C@]3(CO3)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O.O=P(O)(O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Oleandomycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KCNH2 known ✓ Q12809 5/20 0.42
CYP3A4 P08684 12/20 1.00
LMNA P02545 3/20 0.94
ABCB1 P08183 3/20 0.68
USP2 O75604 2/20 0.68
MLNR O43193 4/20 0.43
AR P10275 1/20 0.42
MAPK1 P28482 1/20 0.42
SLCO1B3 Q9NPD5 1/20 0.42
SLCO1B1 Q9Y6L6 1/20 0.42
TSHR P16473 2/20 0.42
TDP1 Q9NUW8 1/20 0.41
ALB P02768 1/20 0.41
CNR1 P21554 1/20 0.41
HTR2A P28223 1/20 0.41
AOX1 Q06278 1/20 0.41
CYP1B1 Q16678 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oleandomycin SCHEMBL5033021 1.00 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL3717 0.97 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL3716 0.97 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL29684259 0.97 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL10028439 0.97 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL9807053 0.96 CYP3A4 (0.99) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL950913 0.95 CYP3A4 (0.96) CYP3A4LMNAABCB1USP2MLNR
SCHEMBL11029029 0.89 CYP3A4 (0.85) CYP3A4LMNAABCB1USP2MLNR
Diproleandomycin SCHEMBL2109038 0.84 CYP3A4 (0.78) CYP3A4LMNAABCB1USP2MLNR
SCHEMBL5551907 0.83 CYP3A4 (0.74) CYP3A4LMNAABCB1USP2MLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 332 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113559264-A Methods of treating microbial infections including mastitis 罗达制药公司 2021-10-29 CN claimed
CN-113144197-A Method of treating topical microbial infections 罗达制药公司 2021-07-23 CN claimed
EP-2953624-B1 METHODS OF TREATING MICROBIAL INFECTIONS, INCLUDING MASTITIS LUODA PHARMA LTD (IE) 2019-08-21 EP claimed
US-20190038655-A1 CHEMICALS AND METHODS TO PREVENT AND TREAT TGF-BETA MEDIATED ACTIVATION OF FIBROBLASTS TO REDUCE AND TREAT CANCER AND FIBROSIS BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE 2019-02-07 US claimed
EP-3411045-A1 CHEMICALS AND METHODS TO PREVENT AND TREAT TGF-BETA MEDIATED ACTIVATION OF FIBROBLASTS TO REDUCE AND TREAT CANCER AND FIBROSIS Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (US) 2018-12-12 EP claimed
WO-2017136515-A1 CHEMICALS AND METHODS TO PREVENT AND TREAT TGF-BETA MEDIATED ACTIVATION OF FIBROBLASTS TO REDUCE AND TREAT CANCER AND FIBROSIS CARDELLI JAMES ALLEN (US) 2017-08-10 WO claimed
US-20170128379-A1 MODIFIED RELEASE PHARMACEUTICAL PREPARATIONS RUBICON RESEARCH PRIVATE LIMITED (IN) 2017-05-11 US claimed
US-20160000748-A1 METHODS OF TREATING TOPICAL MICROBIAL INFECTIONS Luoda Pharma Limited (IE) 2016-01-07 US claimed
WO-2016001937-A2 MODIFIED RELEASE PHARMACEUTICAL PREPARATIONS RUBICON RESEARCH PRIVATE LIMITED (IN) 2016-01-07 WO claimed
US-20150366797-A1 METHODS OF TREATING MICROBIAL INFECTIONS, INCLUDING MASTITIS Luoda Pharma Limited (IE) 2015-12-24 US claimed
EP-2953623-A1 METHODS OF TREATING TOPICAL MICROBIAL INFECTIONS Luoda Pharma Pty Ltd (AU) 2015-12-16 EP claimed
EP-2953624-A1 METHODS OF TREATING MICROBIAL INFECTIONS, INCLUDING MASTITIS Luoda Pharma Pty Ltd (AU) 2015-12-16 EP claimed
WO-2014121342-A1 METHODS OF TREATING TOPICAL MICROBIAL INFECTIONS LUODA PHARMA PTY LIMITED (AU) 2014-08-14 WO claimed
US-20100221245-A1 TOPICAL SKIN CARE COMPOSITION DERMADOCTOR, LLC 2010-09-02 US claimed
US-20260027191-A1 COMPOSITIONS AND METHODS FOR TREATING BACTERIAL DISEASE UNIV ARIZONA (US) 2026-01-29 US disclosed
US-20260014384-A1 RESORBABLE NONWOVEN POUCHES FOR MEDICAL DEVICE IMPLANTS TEPHA, INC. (US) 2026-01-15 US disclosed
US-12440687-B2 Resorbable nonwoven pouches for medical device implants TEPHA, INC. (US) 2025-10-14 US disclosed
US-4539234-A Urethral catheter capable of preventing urinary tract infection and process for producing the same UNITIKA LTD. (JP) 1985-09-03 US disclosed
EP-0065884-A1 Urethral catheter capable of preventing urinary tract infection and process for producing the same UNITIKA LTD. (JP) 1982-12-01 EP disclosed
US-4102806-A DISPERSION TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1978-07-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160000748-A1 METHODS OF TREATING TOPICAL MICROBIAL INFECTIONS TSLP, CCL11, IL17A KCNH2 1514/4885CYP3A4 4224/4885LMNA 4594/4885
US-20150366797-A1 METHODS OF TREATING MICROBIAL INFECTIONS, INCLUDING MASTITIS LCT, TSLP, MLEC KCNH2 737/4885CYP3A4 4664/4885LMNA 4632/4885
US-20260014384-A1 RESORBABLE NONWOVEN POUCHES FOR MEDICAL DEVICE IMPLANTS MLN, TNNC1, VIP KCNH2 691/4885CYP3A4 700/4885LMNA 3992/4885
US-20260027191-A1 COMPOSITIONS AND METHODS FOR TREATING BACTERIAL DISEASE DNMT3L, DNMT3A, DNMT1 KCNH2 4126/4885CYP3A4 3633/4885LMNA 1451/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.