SCHEMBL37165

SCHEMBL37165

Cc1cc(C)c(CC(=O)Cl)c(C)c1

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.40
MAPT P10636 2/20 0.40
POLB P06746 2/20 0.40
TSHR P16473 2/20 0.38
LMNA P02545 1/20 0.37
ALDH1A1 P00352 4/20 0.37
HPGD P15428 2/20 0.36
HTT P42858 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
TPMT P51580 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
HRH3 Q9Y5N1 1/20 0.34
HTR1D P28221 1/20 0.34
HTR1B P28222 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6841350 0.88 TSHR (0.45) KDM4EMAPTPOLBTSHRLMNA
SCHEMBL37414 0.84 P2RX7 (0.35) KDM4EMAPTALDH1A1SMN1; SMN2TPMT
SCHEMBL3420493 0.83 ALDH1A1 (0.37) KDM4EMAPTPOLBALDH1A1HPGD
SCHEMBL14834234 0.82 POLB (0.33) KDM4EMAPTPOLBTSHRLMNA
SCHEMBL12214120 0.81 KDM4E (0.42) KDM4EMAPTPOLBTSHRLMNA
SCHEMBL1259503 0.79 KDM4E (0.41) KDM4EMAPTPOLBTSHRLMNA
SCHEMBL509440 0.79 KDM4E (0.58) KDM4EMAPTPOLBTSHRLMNA
SCHEMBL3476152 0.79 KDM4E (0.41) KDM4EMAPTPOLBTSHRLMNA
SCHEMBL466415 0.78 GSK3B (0.35) KDM4EMAPTPOLBTSHRALDH1A1
SCHEMBL3011945 0.78 ALDH1A1 (0.41) KDM4EMAPTPOLBTSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 178 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115850059-B Improved synthesis process of 2,4, 6-trimethylphenylacetyl chloride 大连奇凯医药科技有限公司 2024-03-22 CN claimed
CN-115850059-A Improved synthesis process of 2,4, 6-trimethylbenzene acetyl chloride 大连奇凯医药科技有限公司 2023-03-28 CN claimed
CN-115850059-B Improved synthesis process of 2,4, 6-trimethylphenylacetyl chloride 大连奇凯医药科技有限公司 2024-03-22 CN disclosed
CN-115850059-B Improved synthesis process of 2,4, 6-trimethylphenylacetyl chloride 大连奇凯医药科技有限公司 2024-03-22 CN disclosed
CN-115850059-B Improved synthesis process of 2,4, 6-trimethylphenylacetyl chloride 大连奇凯医药科技有限公司 2024-03-22 CN disclosed
CN-115850059-A Improved synthesis process of 2,4, 6-trimethylbenzene acetyl chloride 大连奇凯医药科技有限公司 2023-03-28 CN disclosed
CN-115850059-A Improved synthesis process of 2,4, 6-trimethylbenzene acetyl chloride 大连奇凯医药科技有限公司 2023-03-28 CN disclosed
CN-115850059-A Improved synthesis process of 2,4, 6-trimethylbenzene acetyl chloride 大连奇凯医药科技有限公司 2023-03-28 CN disclosed
EP-2575469-B1 PESTICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2018-03-14 EP disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 US disclosed
EP-2575472-B1 METHOD OF CONTROLLING NEONICOTINOID RESISTANT HEMIPTERA USING SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-07-19 EP disclosed
US-5258527-A Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives BAYER AKTIENGESELLSCHAFT (DE) 1993-11-02 US disclosed
US-5225434-A PESTICIDAL AND HERBICIDAL POLYCYCLIC 3-ARYL-PYRROLIDINE-2,4-DIONE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 1993-07-06 US disclosed
US-5186737-A Herbicides BAYER AKTIENGESELLSCHAFT (DE) 1993-02-16 US disclosed
WO-1992016510-A1 NOVEL HERBICIDALLY, ACARICIDALLY AND INSECTICIDALLY ACTIVE COMPOUNDS CIBA-GEIGY AG (CH) 1992-10-01 WO disclosed
US-5142065-A Intermediates for herbicides, fungicides, miticides and insecticides BAYER AKTIENGESELLSCHAFT (DE) 1992-08-25 US disclosed
US-5116836-A Herbicides, insecticides, miticides BAYER AKTIENGESELLSCHAFT (DE) 1992-05-26 US disclosed
US-5091537-A Acylamino acid ester derivatives; insecticide, fungicide, herbicide, acaricide, and antimycotic agent BAYER AKTIENGESELLSCHAFT (DE) 1992-02-25 US disclosed
US-5045560-A Insecticides, nematocides, fungicides, herbicides, human and veterinary medicine BAYER AKTIENGESELLSCHAFT (DE) 1991-09-03 US disclosed
US-4985063-A INSECTICIDES, MITICIDES, HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1991-01-15 US disclosed