Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL918915 | 0.90 | P2RX7 (0.43) | P2RX7KDM4EABCB1 | |
| SCHEMBL37165 | 0.84 | KDM4E (0.40) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL31236753 | 0.83 | P2RX7 (0.35) | P2RX7KDM4ETP53ALOX15ALDH1A1 | |
| SCHEMBL31236754 | 0.83 | P2RX7 (0.35) | P2RX7KDM4ETP53ALOX15ALDH1A1 | |
| SCHEMBL6394892 | 0.83 | AKR1B1 (0.47) | KDM4EALDH1A1MEN1GAAMAPT | |
| SCHEMBL812155 | 0.81 | SHMT1 (0.39) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3420493 | 0.81 | ALDH1A1 (0.37) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL21049510 | 0.81 | HTT (0.42) | ALDH1A1MEN1KMT2A | |
| SCHEMBL13527344 | 0.78 | ALDH1A1 (0.54) | KDM4ETP53ALOX15ALDH1A1MEN1 | |
| SCHEMBL6841350 | 0.78 | TSHR (0.45) | KDM4EALDH1A1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3494109-B1 | PROCESS FOR THE PREPARATION OF SPIROKETAL-SUBSTITUTED CYCLIC KETOENOLS | BAYER CROPSCIENCE AG (DE) | 2024-10-23 | — | — | EP | disclosed |
| EP-3774761-B1 | METHOD FOR THE PREPARATION OF CYCLOHEXANAMINO ACID ESTERS AND SPIROKETAL SUBSTITUTED CYCLIC KETOENOLS | BAYER AG (DE) | 2024-09-11 | — | — | EP | disclosed |
| US-20240294539-A1 | PROCESS FOR PREPARING SUBSTITUTED CYCLOHEXANE AMINO ACID ESTERS AND SPIROKETAL-SUBSTITUTED CYCLIC KETO-ENOLS | BAYER AKTIENGESELLSCHAFT (DE) | 2024-09-05 | — | — | US | disclosed |
| US-12006327-B2 | Process for preparing substituted cyclohexane amino acid esters and spiroketal-substituted cyclic keto-enols | BAYER AKTIENGESELLSCHAFT (DE) | 2024-06-11 | — | — | US | disclosed |
| CN-112041310-B | Method for producing N-acylated amino acid esters comprising ketone protecting groups with acid-instability | 拜耳公司 | 2023-11-03 | — | — | CN | disclosed |
| CN-109563066-B | Process for preparing spiroketal-substituted cyclic ketoenols | 拜耳作物科学股份公司 | 2023-08-29 | — | — | CN | disclosed |
| US-20220267291-A1 | PROCESS FOR PREPARING ESTERS OF N-ACYLATED AMINO ACIDS WITH ACID-LABILE KETO PROTECTIVE GROUP FUNCTIONS | BAYER AKTIENGESELLSCHAFT (DE) | 2022-08-25 | — | — | US | disclosed |
| US-11384061-B2 | Process for preparing esters of N-acylated amino acids with acid-labile keto protective group functions | BAYER AKTIENGESELLSCHAFT (DE) | 2022-07-12 | — | — | US | disclosed |
| US-11384061-B2 | Process for preparing esters of N-acylated amino acids with acid-labile keto protective group functions | BAYER AKTIENGESELLSCHAFT (DE) | 2022-07-12 | — | — | US | disclosed |
| US-11220511-B2 | Process for preparing spiroketal-substituted cyclic ketoenols | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2022-01-11 | — | — | US | disclosed |
| WO-2011151249-A2 | METHOD OF CONTROLLING NEONICOTINOID RESISTANT HEMIPTERA | SYNGENTA PARTICIPATIONS AG (CH) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151247-A2 | PESTICIDAL COMPOSITIONS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151248-A1 | PESTICIDAL COMPOSITIONS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-12-08 | — | — | WO | disclosed |
| US-20110224079-A1 | SPIROHETEROCYCLIC N-OXYAMIDES AS PESTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2011-09-15 | — | — | US | disclosed |
| EP-2352376-A1 | SPIROHETEROCYCLIC N-OXYAMIDES AS PESTICIDES | Syngenta Participations AG (CH) | 2011-08-10 | — | — | EP | disclosed |
| US-20110190493-A1 | Spiroketal-Substituted Cyclic Ketoenols | BAYER CROPSCIENCE AG (DE) | 2011-08-04 | — | — | US | disclosed |
| US-7897543-B2 | Spiroketal-substituted cyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2011-03-01 | — | — | US | disclosed |
| US-20100279873-A1 | Halogen Alkoxy Spirocyclic Tetramic and Tetronic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2010-11-04 | — | — | US | disclosed |
| WO-2010063670-A1 | SPIROHETEROCYCLIC N-OXYAMIDES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2010-06-10 | — | — | WO | disclosed |
| US-20080305955-A1 | Spiroketal-Substituted Cyclic Ketoenols | BAYER CROPSCIENCE AG (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11220511-B2 | Process for preparing spiroketal-substituted cyclic ketoenols | AKR1C2, AKR1C4, AKR1C3 | P2RX7 2343/4885KDM4E 344/4885TP53 4693/4885 |
| US-20110190493-A1 | Spiroketal-Substituted Cyclic Ketoenols | AKR1D1, PDHX, KHK | P2RX7 1094/4885KDM4E 476/4885TP53 3378/4885 |
| US-20100279873-A1 | Halogen Alkoxy Spirocyclic Tetramic and Tetronic Acid Derivatives | KCNA5, KCNH1, KCNQ5 | P2RX7 939/4885KDM4E 3536/4885TP53 1867/4885 |
| US-11384061-B2 | Process for preparing esters of N-acylated amino acids with acid-labile keto protective group functions | AADAT, DNPEP, BCKDK | P2RX7 4878/4885KDM4E 873/4885TP53 3853/4885 |
| US-20240294539-A1 | PROCESS FOR PREPARING SUBSTITUTED CYCLOHEXANE AMINO ACID ESTERS AND SPIROKETAL-SUBSTITUTED CYCLIC KETO-ENOLS | BCAT1, BCAT2, BCKDK | P2RX7 4702/4885KDM4E 873/4885TP53 4164/4885 |
| US-12006327-B2 | Process for preparing substituted cyclohexane amino acid esters and spiroketal-substituted cyclic keto-enols | BCAT1, BCAT2, BCKDK | P2RX7 4702/4885KDM4E 873/4885TP53 4164/4885 |
| US-20080305955-A1 | Spiroketal-Substituted Cyclic Ketoenols | AKR1D1, PDHX, KHK | P2RX7 1094/4885KDM4E 476/4885TP53 3378/4885 |
| US-20220267291-A1 | PROCESS FOR PREPARING ESTERS OF N-ACYLATED AMINO ACIDS WITH ACID-LABILE KETO PROTECTIVE GROUP FUNCTIONS | AADAT, DNPEP, BCKDK | P2RX7 4878/4885KDM4E 873/4885TP53 3853/4885 |
| US-20110224079-A1 | SPIROHETEROCYCLIC N-OXYAMIDES AS PESTICIDES | DDT, ODC1, ACHE | P2RX7 1996/4885KDM4E 2733/4885TP53 4863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.