Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3803815 | 0.84 | EPHX2 (0.49) | ALDH1A1MAPTPOLBKMT2APPARG | |
| SCHEMBL3793849 | 0.82 | MAPT (0.46) | ALDH1A1MAPTPOLBKMT2APPARG | |
| SCHEMBL3724166 | 0.81 | ALDH1A1 (0.46) | ALDH1A1MAPTPOLBKMT2APPARG | |
| SCHEMBL3716663 | 0.81 | ALDH1A1 (0.48) | ALDH1A1MAPTPOLBKMT2APPARG | |
| SCHEMBL13075758 | 0.80 | MAPT (0.45) | ALDH1A1MAPTPOLBKMT2APPARG | |
| SCHEMBL13076533 | 0.80 | MAPT (0.44) | ALDH1A1MAPTPOLBKMT2APPARG | |
| SCHEMBL13075698 | 0.77 | EPHX2 (0.45) | ALDH1A1MAPTPOLBKMT2APPARG | |
| SCHEMBL13075757 | 0.73 | GRIN1 (0.51) | EPHX2LMNA | |
| SCHEMBL13076485 | 0.73 | GRIN1 (0.50) | ALDH1A1PPARGEPHX2KDM4ELMNA | |
| SCHEMBL3722318 | 0.71 | CD274 (0.46) | ALDH1A1KDM4ECNR2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129848-A2 | 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010129848-A2 | 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-11 | — | — | WO | disclosed |