SCHEMBL3727322

SCHEMBL3727322

C#CCNc1nc(CN)cc(-c2ccc(Br)cc2)n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 1/20 0.43
PYCR1 P32322 1/20 0.38
KCNH3 Q9ULD8 1/20 0.37
KDM4E B2RXH2 3/20 0.36
SYK P43405 2/20 0.35
MAOA P21397 2/20 0.33
MAOB P27338 2/20 0.33
PIK3CG P48736 2/20 0.33
ACHE P22303 2/20 0.33
PIK3CA P42336 1/20 0.33
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33
MAPT P10636 2/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.33
SLC2A1 P11166 1/20 0.33
MGAM O43451 1/20 0.32
GAA P10253 1/20 0.32
SI P14410 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3723261 0.81 PTGS1 (0.48) AGTR1KCNH3KDM4ESYKMAPT
SCHEMBL3722029 0.80 L3MBTL1 (0.44) AGTR1KDM4ESYKACHEMAPT
SCHEMBL3727320 0.79 SCN9A (0.43) AGTR1PYCR1KDM4EALDH1A1LMNA
SCHEMBL3723229 0.78 ADORA1 (0.48) KDM4EADORA2AADORA1ALDH1A1HPGD
SCHEMBL3727142 0.75 AGTR1 (0.43) AGTR1KDM4EMAPTALDH1A1LMNA
SCHEMBL3723029 0.74 KDM4E (0.53) KDM4EALDH1A1LMNAGAACCNE1
SCHEMBL3720119 0.73 ACP1 (0.44) AGTR1KDM4ESYKPIK3CGPIK3CA
SCHEMBL3720866 0.73 KDM4E (0.46) AGTR1KDM4EMAPTALDH1A1LMNA
SCHEMBL3720305 0.72 PIK3CA (0.43) AGTR1PIK3CGPIK3CAMGAMGAA
SCHEMBL3717784 0.72 ACP1 (0.47) ACHEALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed