Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexketoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 6/20 | 0.97 |
| ▸ | PTGS2 known ✓ | P35354 | 6/20 | 0.97 |
| ▸ | MAPT | P10636 | 5/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 0.97 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.97 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | RECQL | P46063 | 1/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.97 |
| ▸ | HPGD | P15428 | 1/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.97 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.97 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.97 |
| ▸ | THPO | P40225 | 1/20 | 0.97 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.97 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ketoprofen SCHEMBL1248409 | 1.00 | PTGS1 (0.97) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| R-Ketoprofen SCHEMBL29353694 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL3843886 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Dexketoprofen SCHEMBL66987 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL16757741 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Dexketoprofen SCHEMBL29396875 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL679920 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| R-Ketoprofen SCHEMBL195303 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL8754790 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL8577572 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996016017-A1 | NOVEL ARYLPROPIONIC DERIVATIVES WITH ANALGESIC ACTION AND THE PROCESS FOR THE PREPARATION THEREOF | LABORATORIOS MENARINI S.A. (ES) | 1996-05-30 | — | — | WO | claimed |
| US-20160220574-A1 | NSAID AND SIGMA RECEPTOR LIGAND COMBINATIONS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2016-08-04 | — | — | US | disclosed |
| EP-3043795-A1 | NSAID AND SIGMA RECEPTOR LIGAND COMBINATIONS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015036470-A1 | NSAID AND SIGMA RECEPTOR LIGAND COMBINATIONS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2015-03-19 | — | — | WO | disclosed |
| US-20050004118-A1 | Prodrugs of non-steroidal anti-inflammatory and carboxylic acid containing compounds | JILANI JAMAL A (JO) | 2005-01-06 | — | — | US | disclosed |
| US-20030060465-A1 | Prodrugs of non-steroidal anti-inflammatory and carboxylic acid containing compounds | SPECIALIZED PHARMACEUTICAL RESEARCH LTD. CO. (JO) | 2003-03-27 | — | — | US | disclosed |
| EP-1231209-A1 | Prodrugs of non-steroidal anti-inflammatory and carboxylic acid containing compound | Specialized Pharmaceutical Research Ltd. Co. (JO) | 2002-08-14 | — | — | EP | disclosed |
| WO-1996016017-A1 | NOVEL ARYLPROPIONIC DERIVATIVES WITH ANALGESIC ACTION AND THE PROCESS FOR THE PREPARATION THEREOF | LABORATORIOS MENARINI S.A. (ES) | 1996-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004118-A1 | Prodrugs of non-steroidal anti-inflammatory and carboxylic acid containing compounds | HCAR2, NONO, ALOX15 | PTGS1 11/4885PTGS2 14/4885MAPT 4622/4885 |
| US-20030060465-A1 | Prodrugs of non-steroidal anti-inflammatory and carboxylic acid containing compounds | NONO, CCNO, HCAR2 | PTGS1 10/4885PTGS2 14/4885MAPT 4598/4885 |
| US-20160220574-A1 | NSAID AND SIGMA RECEPTOR LIGAND COMBINATIONS | SIGMAR1, OPRL1, OPRK1 | PTGS1 26/4885PTGS2 73/4885MAPT 3886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.