Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3726417 | 0.88 | TACR2 (0.42) | CDK1APPCCNE1CDK2CCNE2 | |
| SCHEMBL3724956 | 0.88 | CDK2 (0.42) | CDK1APPCCNE1CDK2CCNE2 | |
| SCHEMBL2910733 | 0.87 | CDK2 (0.52) | CDK1APPCCNE1CDK2CCNE2 | |
| SCHEMBL3718660 | 0.84 | CDK2 (0.55) | CDK1CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL3714767 | 0.84 | CDK2 (0.43) | CDK1CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL3718378 | 0.82 | CDK2 (0.43) | CDK1MEN1KMT2ACCNE1CDK2 | |
| SCHEMBL3720176 | 0.82 | TACR2 (0.49) | CDK1CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL3725653 | 0.82 | CDK2 (0.46) | CDK1CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL3799897 | 0.81 | CDK2 (0.56) | CDK1CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL2910995 | 0.81 | CDK2 (0.52) | CDK1APPCCNE1CDK2CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010139288-A1 | 5,7-DISUBSTITUTED 3-ISOPROPYLPYRAZOLO[4,3-D]PYRIMIDINES FOR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS | C3 BIO GMBH (DE) | 2010-12-09 | — | — | WO | disclosed |