Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13191262 | 0.89 | RORC (0.33) | P2RX7MEN1KMT2ANPSR1BDKRB1 | |
| SCHEMBL13191701 | 0.88 | KMT2A (0.38) | P2RX7MEN1KMT2ANPSR1EPHX2 | |
| SCHEMBL13191622 | 0.88 | EPHX2 (0.47) | P2RX7MEN1KMT2AEPHX2BDKRB1 | |
| SCHEMBL13191624 | 0.87 | EPHX2 (0.40) | P2RX7EPHX2BDKRB1 | |
| SCHEMBL3718251 | 0.87 | P2RX7 (0.39) | P2RX7MEN1KMT2ANPSR1EPHX2 | |
| SCHEMBL13191616 | 0.86 | P2RX7 (0.38) | P2RX7EPHX2BDKRB1 | |
| SCHEMBL3722271 | 0.86 | BDKRB1 (0.43) | P2RX7EPHX2BDKRB1CNR1 | |
| SCHEMBL13191647 | 0.86 | P2RX7 (0.37) | P2RX7MEN1KMT2ANPSR1EPHX2 | |
| SCHEMBL13191237 | 0.86 | RAB9A (0.40) | P2RX7EPHX2BDKRB1 | |
| SCHEMBL13191643 | 0.86 | P2RX7 (0.39) | P2RX7KMT2AEPHX2BDKRB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097373-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |
| WO-2010097373-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |