Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264503 | 0.92 | HDAC3 (0.48) | HDAC3HDAC1HDAC2HDAC6OPRD1 | |
| SCHEMBL751730 | 0.84 | OPRD1 (0.47) | HDAC3HDAC1HDAC2HDAC6OPRD1 | |
| SCHEMBL6538566 | 0.76 | DRD2 (0.51) | OPRD1OPRK1CCR1NOS2CCR5 | |
| SCHEMBL8315425 | 0.76 | OPRD1 (0.54) | OPRD1OPRK1CCR1NOS2OPRM1 | |
| SCHEMBL14922381 | 0.75 | CHRM4 (0.50) | HDAC3HDAC1HDAC2HDAC6OPRD1 | |
| SCHEMBL3662100 | 0.75 | LMNA (0.43) | OPRD1OPRK1OPRM1MEN1KMT2A | |
| SCHEMBL7556949 | 0.74 | CHRM4 (0.61) | HDAC3HDAC1HDAC2HDAC6OPRD1 | |
| SCHEMBL6043019 | 0.74 | GPR119 (0.52) | OPRD1OPRK1CCR1MEN1KMT2A | |
| SCHEMBL2265088 | 0.73 | MEN1 (0.69) | HDAC3HDAC1HDAC2HDAC6OPRD1 | |
| SCHEMBL751049 | 0.73 | OPRD1 (0.53) | HDAC3HDAC1HDAC2HDAC6OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2235010-A1 | BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS | AstraZeneca AB (SE) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009081197-A1 | BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | disclosed |