Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 11/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720129 | 0.88 | ACACB (0.37) | SCN9AMAPTHCAR3 | |
| SCHEMBL3721953 | 0.88 | SCN9A (0.36) | SCN9AMAP4K4 | |
| SCHEMBL3720524 | 0.83 | SMN1; SMN2 (0.39) | ELANESCN9ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL3722768 | 0.83 | MTNR1A (0.50) | SCN9ASMN1; SMN2 | |
| SCHEMBL3721952 | 0.82 | SCN9A (0.37) | SCN9AHCAR3MAP4K4 | |
| SCHEMBL3720127 | 0.80 | PDE4B (0.49) | SCN9AHCAR3 | |
| SCHEMBL22521622 | 0.79 | ELANE (0.45) | ELANESMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL3716766 | 0.77 | SMN1; SMN2 (0.43) | SCN9ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL3722765 | 0.77 | ACACB (0.45) | SCN9A | |
| SCHEMBL3725263 | 0.73 | MAPT (0.42) | SMN1; SMN2NPC1RAB9AMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |