Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716766 | 0.90 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9ACYP1A2CYP2A6 | |
| SCHEMBL3720339 | 0.89 | HTT (0.34) | SMN1; SMN2CYP1A2PDE4BKDM4ECYP2C9 | |
| SCHEMBL3726251 | 0.87 | SCN9A (0.33) | CYP1A2PDE4BKDM4ECYP2C9CYP2C19 | |
| SCHEMBL3722383 | 0.87 | CYP1A2 (0.35) | RAB9ACYP1A2KDM4ECYP2C9CYP2C19 | |
| SCHEMBL3725263 | 0.85 | MAPT (0.42) | SMN1; SMN2NPC1RAB9ACYP1A2CYP2A6 | |
| SCHEMBL3720074 | 0.83 | JAK2 (0.36) | SMN1; SMN2NPC1RAB9AELANECYP1A2 | |
| SCHEMBL3722368 | 0.83 | HTT (0.52) | SMN1; SMN2NPC1RAB9ACYP1A2KDM4E | |
| SCHEMBL3720909 | 0.82 | RAB9A (0.39) | SMN1; SMN2NPC1RAB9ACYP1A2CYP2A6 | |
| SCHEMBL3717019 | 0.82 | CYP1A2 (0.43) | SMN1; SMN2NPC1RAB9ACYP1A2CYP2A6 | |
| SCHEMBL3722417 | 0.81 | MEN1 (0.38) | SMN1; SMN2NPC1RAB9APDE4BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |