Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720723 | 0.87 | MAPT (0.44) | MAPTHRH3ELANEALDH1A1HPGD | |
| SCHEMBL3725385 | 0.86 | MAPT (0.43) | MAPTHPGDCYP2C9ACACB | |
| SCHEMBL3719433 | 0.86 | MAPT (0.39) | MAPTSCN7AELANEHPGDTLR8 | |
| SCHEMBL3720292 | 0.85 | MAPT (0.41) | MAPTSCN7AALDH1A1TLR8CYP2C19 | |
| SCHEMBL3726852 | 0.85 | P2RX3 (0.43) | MAPTELANEALDH1A1POLBACACB | |
| SCHEMBL3716747 | 0.82 | MAPT (0.39) | MAPTSCN7AELANEKDM4EPOLB | |
| SCHEMBL3717824 | 0.81 | ALDH1A1 (0.45) | MAPTKDM4EALDH1A1POLBCYP2C9 | |
| SCHEMBL3720087 | 0.81 | MAPT (0.38) | MAPTSCN7AKDM4EACACBLMNA | |
| SCHEMBL3718215 | 0.80 | PIK3CA (0.40) | MAPTSCN9A | |
| SCHEMBL3719557 | 0.79 | MAPT (0.42) | MAPTACACBSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |