Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720187 | 0.84 | MAPT (0.32) | MAPTELANELMNACYP1A2CYP2C19 | |
| SCHEMBL3726852 | 0.84 | P2RX3 (0.43) | MAPTPOLBATMBLML3MBTL1 | |
| SCHEMBL3720475 | 0.84 | HTT (0.37) | MAPTPOLBATML3MBTL1LMNA | |
| SCHEMBL3727694 | 0.84 | MAPT (0.32) | MAPTLMNACYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL3720114 | 0.82 | MAPT (0.46) | MAPTPOLBELANELMNACYP2C19 | |
| SCHEMBL3717824 | 0.81 | ALDH1A1 (0.45) | MAPTPOLBATMBLML3MBTL1 | |
| SCHEMBL3720292 | 0.80 | MAPT (0.41) | MAPTLMNACYP1A2CYP2C19HIF1A | |
| SCHEMBL3727136 | 0.78 | MAPT (0.34) | MAPTELANE | |
| SCHEMBL3720633 | 0.77 | SMN1; SMN2 (0.33) | LMNACYP1A2CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL3716750 | 0.77 | CYP1A2 (0.35) | LMNACYP1A2SMN1; SMN2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |