Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.59 |
| ▸ | MMP12 | P39900 | 1/20 | 0.59 |
| ▸ | MMP13 | P45452 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17147370 | 0.77 | MMP8 (0.57) | MMP8MMP12MMP13ALDH1A1L3MBTL1 | |
| SCHEMBL15832924 | 0.75 | MMP8 (0.87) | MMP8MMP12MMP13ALDH1A1L3MBTL1 | |
| SCHEMBL894072 | 0.74 | MMP8 (1.00) | MMP8MMP12MMP13ALDH1A1L3MBTL1 | |
| SCHEMBL894074 | 0.74 | MMP8 (1.00) | MMP8MMP12MMP13ALDH1A1L3MBTL1 | |
| SCHEMBL16217966 | 0.73 | MMP8 (0.66) | MMP8MMP12MMP13ALDH1A1L3MBTL1 | |
| SCHEMBL16217965 | 0.72 | MMP8 (0.64) | MMP8MMP12MMP13ALDH1A1L3MBTL1 | |
| SCHEMBL25989026 | 0.71 | L3MBTL1 (0.76) | MMP8MMP12MMP13ALDH1A1L3MBTL1 | |
| SCHEMBL17147374 | 0.71 | ELOVL6 (0.35) | ALDH1A1L3MBTL1TDP1POLBHTT | |
| SCHEMBL3717775 | 0.71 | POLB (0.56) | MMP8MMP12MMP13ALDH1A1L3MBTL1 | |
| SCHEMBL3802592 | 0.70 | MAPT (0.46) | MMP8ALDH1A1L3MBTL1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| US-9562043-B2 | Heterocyclic amide derivative and pharmaceutical product containing same | EA PHARMA CO., LTD. (JP) | 2017-02-07 | — | — | US | disclosed |
| US-9562043-B2 | Heterocyclic amide derivative and pharmaceutical product containing same | EA PHARMA CO., LTD. (JP) | 2017-02-07 | — | — | US | disclosed |
| EP-2937335-A1 | HETEROCYCLIC AMIDE DERIVATIVE, AND MEDICINE CONTAINING SAME | Ajinomoto Co., Inc. (JP) | 2015-10-28 | — | — | EP | disclosed |
| US-20150284375-A1 | HETEROCYCLIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME | AJINOMOTO CO., INC. (JP) | 2015-10-08 | — | — | US | disclosed |
| US-20140329796-A1 | HETEROCYCLIC AMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | AJINOMOTO CO., INC. (JP) | 2014-11-06 | — | — | US | disclosed |
| US-20140329796-A1 | HETEROCYCLIC AMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | AJINOMOTO CO., INC. (JP) | 2014-11-06 | — | — | US | disclosed |
| WO-2014098098-A1 | HETEROCYCLIC AMIDE DERIVATIVE, AND MEDICINE CONTAINING SAME | 味の素株式会社 (JP) | 2014-06-26 | — | — | WO | disclosed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284375-A1 | HETEROCYCLIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME | TRPA1, TRPV1, TRPV2 | MMP8 1141/4885MMP12 2543/4885MMP13 2861/4885 |
| US-20140329796-A1 | HETEROCYCLIC AMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | TRPA1, TRPV1, TRPV2 | MMP8 1988/4885MMP12 3312/4885MMP13 3558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.