Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.45 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717681 | 0.87 | HTT (0.49) | HTTSMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL3720171 | 0.86 | MTNR1A (0.57) | HTTSMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL3720524 | 0.83 | SMN1; SMN2 (0.39) | HTTSMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL3725263 | 0.83 | MAPT (0.42) | SMN1; SMN2RAB9ANPC1POLBALDH1A1 | |
| SCHEMBL3720909 | 0.81 | RAB9A (0.39) | SMN1; SMN2RAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL3717019 | 0.81 | CYP1A2 (0.43) | SMN1; SMN2RAB9ANPC1POLBALDH1A1 | |
| SCHEMBL3717678 | 0.79 | HTT (0.50) | HTTSMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL3716766 | 0.79 | SMN1; SMN2 (0.43) | HTTSMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL3720168 | 0.78 | HTT (0.49) | HTTSMN1; SMN2POLBALDH1A1HPGD | |
| SCHEMBL3724569 | 0.78 | MTNR1A (0.55) | SMN1; SMN2ALDH1A1HPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |