Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.37 |
| ▸ | CNR1 | P21554 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3726800 | 0.88 | HTR6 (0.40) | CNR2CNR1PSEN1PSEN2APH1B | |
| SCHEMBL676120 | 0.83 | HTR6 (0.44) | ALDH1A1SMN1; SMN2PSEN1PSEN2APH1B | |
| SCHEMBL3730873 | 0.82 | CNR2 (0.38) | CNR2CNR1ALDH1A1SMN1; SMN2PSEN1 | |
| SCHEMBL676078 | 0.82 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2HPGDTSHRHSD17B10 | |
| SCHEMBL3669859 | 0.81 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2HPGDTSHRHSD17B10 | |
| SCHEMBL3721754 | 0.80 | ALDH1A1 (0.40) | CNR2ALDH1A1SMN1; SMN2PSEN1PSEN2 | |
| SCHEMBL3724854 | 0.80 | PSEN1 (0.38) | CNR2SMN1; SMN2PSEN1PSEN2APH1B | |
| SCHEMBL3724852 | 0.80 | PSEN1 (0.38) | CNR2SMN1; SMN2PSEN1PSEN2APH1B | |
| SCHEMBL3728544 | 0.79 | NPC1 (0.42) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3723156 | 0.77 | NOD2 (0.37) | ALDH1A1TSHRGAAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |