SCHEMBL3721963

SCHEMBL3721963

CC(C)c1n[nH]c2c(NCc3ccc(F)c(F)c3F)nc(NCCCN)nc12

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.41
TACR2 P21452 1/20 0.39
CDK2 P24941 9/20 0.39
CCNE1 P24864 7/20 0.39
CCNE2 O96020 4/20 0.39
CCNA2 P20248 3/20 0.39
CCNA1 P78396 3/20 0.39
CDK5 Q00535 2/20 0.36
BCDIN3D Q7Z5W3 2/20 0.34
STK17A Q9UEE5 4/20 0.32
STK17B O94768 1/20 0.32
CCNB2 O95067 3/20 0.32
CDK1 P06493 3/20 0.32
CCNB1 P14635 3/20 0.32
CCNB3 Q8WWL7 3/20 0.32
TDP1 Q9NUW8 1/20 0.32
AURKA O14965 1/20 0.31
CHEK1 O14757 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3724809 0.91 CDK2 (0.40) TACR2CDK2CCNE1CCNE2CCNA2
SCHEMBL3716187 0.87 CDK2 (0.43) TACR2CDK2CCNE1CCNE2CCNA2
SCHEMBL3714767 0.85 CDK2 (0.43) TACR2CDK2CCNE1CCNE2CCNA2
SCHEMBL3725653 0.85 CDK2 (0.46) TACR2CDK2CCNE1CCNE2CCNA2
SCHEMBL3721957 0.83 CDK2 (0.52) P2RX7CDK2CCNE1CCNE2CCNA2
SCHEMBL3719455 0.83 CDK2 (0.52) TACR2CDK2CCNE1CCNE2CCNA2
SCHEMBL3718696 0.83 CDK2 (0.43) TACR2CDK2CCNE1CCNE2CCNA2
SCHEMBL3720176 0.83 TACR2 (0.49) TACR2CDK2CCNE1CCNE2CCNA2
SCHEMBL2910733 0.83 CDK2 (0.52) TACR2CDK2CCNE1CCNE2CCNA2
SCHEMBL3719064 0.83 CYP3A4 (0.43) TACR2CDK2CCNE1CCNE2CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010139288-A1 5,7-DISUBSTITUTED 3-ISOPROPYLPYRAZOLO[4,3-D]PYRIMIDINES FOR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS C3 BIO GMBH (DE) 2010-12-09 WO disclosed