SCHEMBL3724809

SCHEMBL3724809

CC(C)c1n[nH]c2c(NCc3cccc(F)c3F)nc(NCCCN)nc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 8/20 0.40
CCNE1 P24864 7/20 0.40
CCNE2 O96020 4/20 0.40
CCNA2 P20248 3/20 0.40
CCNA1 P78396 3/20 0.40
CDK5 Q00535 2/20 0.37
TACR2 P21452 1/20 0.36
CXCR2 P25025 6/20 0.36
CCR7 P32248 4/20 0.36
CDK7 P50613 1/20 0.35
CCNB2 O95067 1/20 0.35
CDK1 P06493 1/20 0.35
CCNB1 P14635 1/20 0.35
CCNB3 Q8WWL7 1/20 0.35
AURKA O14965 2/20 0.35
PDPK1 O15530 1/20 0.35
RPS6KB1 P23443 1/20 0.35
PRKCQ Q04759 1/20 0.34
KMT2A Q03164 1/20 0.33
NTRK1 P04629 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3716187 0.92 CDK2 (0.43) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3721963 0.91 P2RX7 (0.41) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3719455 0.87 CDK2 (0.52) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3719064 0.86 CYP3A4 (0.43) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3724956 0.85 CDK2 (0.42) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3725653 0.84 CDK2 (0.46) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL2910733 0.84 CDK2 (0.52) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3724807 0.84 CDK2 (0.55) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3718378 0.83 CDK2 (0.43) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3714767 0.83 CDK2 (0.43) CDK2CCNE1CCNE2CCNA2CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010139288-A1 5,7-DISUBSTITUTED 3-ISOPROPYLPYRAZOLO[4,3-D]PYRIMIDINES FOR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS C3 BIO GMBH (DE) 2010-12-09 WO disclosed